Name: IL-4 Polyclonal Antibody
SKU: WP12824
Price: 268 USD
Availability: InStock

Product details

Background:

The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008],

Specifications

Size	50μL/100μL
Target	IL-4
Reactivity	Human, Mouse
Applications	WB, FC, ELISA
MW(Calculated)
MW(Observed)	18kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-2000; Flow Cyt 1:50-200; ELISA 1:5000-20000
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	Synthesized peptide derived from the C-terminal region of human IL-4.
Specificity	IL-4 Polyclonal Antibody detects endogenous levels of IL-4 protein.
Gene Name	IL4
Protein Name	Interleukin-4
Other Name	IL4; / Interleukin-4; / IL-4; / B-cell stimulatory factor 1; / BSF-1; / Binetrakin; / Lymphocyte stimulatory factor 1; / Pitrakinra
Species	Human
Gene ID	3565
Uniprot	P05112,
Species.1	Mouse
Gene ID.1
Uniprot.1	P07750
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Secreted.
Tissue Expression	Blood,PCR rescued clones,
Signaling_pathway	Organismal Systems >> Immune system >> Hematopoietic cell lineage;Organismal Systems >> Immune system >> T cell receptor signaling pathway;Organismal Systems >> Immune system >> Th1 and Th2 cell differentiation;Organismal Systems >> Immune system >> Th17 cell differentiation;Organismal Systems >> Immune system >> IL-17 signaling pathway;Organismal Systems >> Immune system >> Fc epsilon RI signaling pathway;Organismal Systems >> Immune system >> Intestinal immune network for IgA production;Human Diseases >> Cancer: overview >> Pathways in cancer;Human Diseases >> Immune disease >> Asthma;Human Diseases >> Immune disease >> Autoimmune thyroid disease;Human Diseases >> Immune disease >> Inflammatory bowel disease;Human Diseases >> Immune disease >> Allograft rejection;Environmental Information Processing >> Signal transduction >> JAK-STAT signaling pathway;Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway;Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction
Research Areas	>>Cytokine-cytokine receptor interaction; / >>PI3K-Akt signaling pathway; / >>JAK-STAT signaling pathway; / >>Hematopoietic cell lineage; / >>IL-17 signaling pathway; / >>Th1 and Th2 cell differentiation; / >>Th17 cell differentiation; / >>T cell receptor signaling pathway; / >>Fc epsilon RI signaling pathway; / >>Intestinal immune network for IgA production; / >>Leishmaniasis; / >>Pathways in cancer; / >>Asthma; / >>Autoimmune thyroid disease; / >>Inflammatory bowel disease; / >>Allograft rejection
Function	Disease:Genetic variations in IL4 may be a cause of susceptibility to ischemic stroke [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.,Function:Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.,similarity:Belongs to the IL-4/IL-13 family.,

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IL-4 Polyclonal Antibody

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IL-4 Polyclonal Antibody

Product details

Specifications

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