Name: ILKAP Polyclonal Antibody
SKU: WP12831
Price: 268 USD
Availability: InStock

ILKAP Polyclonal Antibody

Ucallm_WP12831-50

Price range: $268.00 through $328.00

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50μl

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SKU: WP12831-100

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Product details

Background:

The protein encoded by this gene is a protein serine/threonine phosphatase of the PP2C family. This protein can interact with integrin-linked kinase (ILK/ILK1), a regulator of integrin mediated signaling, and regulate the kinase activity of ILK. Through the interaction with ILK, this protein may selectively affect the signaling process of ILK-mediated glycogen synthase kinase 3 beta (GSK3beta), and thus participate in Wnt signaling pathway. [provided by RefSeq, Jul 2008],

Specifications

Target	ILKAP
Reactivity	Human, Mouse, Rat, Monkey
Applications	WB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)	45kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Modification
Recommended Dilution Ratio	WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:20000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from human ILKAP. AA range:41-90
Sequence
Specificity	ILKAP Polyclonal Antibody detects endogenous levels of ILKAP protein.
Gene Name	ILKAP
Protein Name	Integrin-linked kinase-associated serine/threonine phosphatase 2C
Other Name	ILKAP; / Integrin-linked kinase-associated serine/threonine phosphatase 2C; / ILKAP
Species	Human
Gene ID-1	80895
Uniprot	Q9H0C8,
Species.1	Mouse
Gene ID-2	67444
Uniprot.1	Q8R0F6,
Species.2	Rat
Gene ID-3	64538
Uniprot.2	Q9Z1Z6
Organism-4
Gene ID-4
SwissProt-4
Background	The protein encoded by this gene is a protein serine/threonine phosphatase of the PP2C family. This protein can interact with integrin-linked kinase (ILK/ILK1), a regulator of integrin mediated signaling, and regulate the kinase activity of ILK. Through the interaction with ILK, this protein may selectively affect the signaling process of ILK-mediated glycogen synthase kinase 3 beta (GSK3beta), and thus participate in Wnt signaling pathway. [provided by RefSeq, Jul 2008],
Cellular Localization	Cytoplasm .
Tissue Expression	Widely expressed. Highest levels expressed in striated muscle. Much lower levels evident in various smooth muscle tissues.
Signaling_pathway
Research Areas
Function	Catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,cofactor:Binds 2 magnesium or manganese ions per subunit.,Function:Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation.,induction:Inhibited rather than stimulated by Magnesium.,similarity:Belongs to the PP2C family.,similarity:Contains 1 PP2C-like domain.,subunit:Interacts with ILK. Specific association with ILK is independent of the catalytic activity of either partner.,tissue specificity:Widely expressed. Highest levels expressed in striated muscle. Much lower levels evident in various smooth muscle tissues.,
RRID

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ILKAP Polyclonal Antibody

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ILKAP Polyclonal Antibody

Product details

Specifications

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