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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/IMDH1 rabbit pAb
SKU: WP16659 Categories: ,

IMDH1 rabbit pAb

Ucallm_WP16659-50

Price range: $268.00 through $328.00

SKU: WP16659-100
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Product details

Background:

The protein encoded by this gene acts as a homotetramer to regulate cell growth. The encoded protein is an enzyme that catalyzes the synthesis of xanthine monophosphate (XMP) from inosine-5'-monophosphate (IMP). This is the rate-limiting step in the de novo synthesis of guanine nucleotides. Defects in this gene are a cause of retinitis pigmentosa type 10 (RP10). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008],

Specifications

TargetIMDH1
ReactivityHuman, Mouse, Rat
ApplicationsWB
MW(Calculated)57kD
MW(Observed)
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Modification
Recommended Dilution RatioWB 1:500-2000
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from human IMDH1 AA range: 304-354
Sequence
SpecificityThis antibody detects endogenous levels of IMDH1 at Human/Mouse/Rat
Gene NameIMPDH1 IMPD1
Protein NameIMDH1
Other Name
SpeciesHuman
Gene ID-13614
UniprotP20839,
Species.1Mouse
Gene ID-223917
Uniprot.1P50096,
Species.2Rat
Gene ID-3
Uniprot.2D3ZLZ7
Organism-4
Gene ID-4
SwissProt-4
BackgroundThe protein encoded by this gene acts as a homotetramer to regulate cell growth. The encoded protein is an enzyme that catalyzes the synthesis of xanthine monophosphate (XMP) from inosine-5' -monophosphate (IMP). This is the rate-limiting step in the de novo synthesis of guanine nucleotides. Defects in this gene are a cause of retinitis pigmentosa type 10 (RP10). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008],
Cellular LocalizationCytoplasm . Nucleus .
Tissue ExpressionIMP type I is the main species in normal leukocytes and type II predominates over type I in the tumor.
Signaling_pathway
Research Areas>>Purine metabolism; / >>Drug metabolism - other enzymes; / >>Metabolic pathways; / >>Nucleotide metabolism
FunctionCatalytic activity:Inosine 5'-phosphate + NAD(+) + H(2)O = xanthosine 5'-phosphate + NADH.,cofactor:Potassium.,Disease:Defects in IMPDH1 are the cause of retinitis pigmentosa type 10 (RP10) [MIM:180105]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP10 inheritance is autosomal dominant.,Function:Rate limiting enzyme in the de novo synthesis of guanine nucleotides and therefore is involved in the regulation of cell growth. It may also have a role in the development of malignancy and the growth progression of some tumors.,online information:Retina International's Scientific Newsletter,pathway:Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.,similarity:Belongs to the IMPDH/GMPR family.,similarity:Contains 2 CBS domains.,subunit:Homotetramer.,tissue specificity:IMP type I is the main species in normal leukocytes and type II predominates over type I in the tumor.,
RRID
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