Name: INSL3 Polyclonal Antibody
SKU: WP15848
Price: 268 USD
Availability: InStock

INSL3 Polyclonal Antibody

Ucallm_WP15848-50

Price range: $268.00 through $328.00

Size

100μl

50μl

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SKU: WP15848-100

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Product details

Background:

This gene encodes a member of the insulin-like hormone superfamily. The encoded protein is mainly produced in gonadal tissues. Studies of the mouse counterpart suggest that this gene may be involved in the development of urogenital tract and female fertility. This protein may also act as a hormone to regulate growth and differentiation of gubernaculum, and thus mediating intra-abdominal testicular descent. Mutations in this gene may lead to cryptorchidism. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2012],

Specifications

Size	50μL/100μL
Target	INSL3
Reactivity	Human, Mouse, Rat
Applications	IHC, IF, ELISA
MW(Calculated)
MW(Observed)
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IHC 1:50-200; ELISA 1:10000-20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	Synthetic peptide from human protein at AA range: 10-50
Specificity	The antibody detects endogenous INSL3
Gene Name	INSL3 RLF RLNL
Protein Name	Insulin-like 3 (Leydig insulin-like peptide) (Ley-I-L) (Relaxin-like factor) [Cleaved into: Insulin-like 3 B chain; Insulin-like 3 A chain]
Other Name	Insulin-like 3; / Leydig insulin-like peptide; / Ley-I-L; / Relaxin-like factor; / [Cleaved into: Insulin-like 3 B chain; / Insulin-like 3 A chain]
Species	Human
Gene ID	3640
Uniprot	P51460,
Species.1	Mouse
Gene ID.1
Uniprot.1	O09107
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Secreted.
Tissue Expression	Expressed in prenatal and postnatal Leydig cells. Found as well in the corpus luteum, trophoblast, fetal membranes and breast.
Signaling_pathway	Organismal Systems >> Endocrine system >> Relaxin signaling pathway
Research Areas	>>Neuroactive ligand-receptor interaction; / >>Relaxin signaling pathway
Function	Disease:Defects in INSL3 seems to be a cause of cryptorchidism [MIM:219050]; also known as impaired testicular descent. It is one of the most frequent congenital abnormalities in humans, involving 2-5% of male births. Cryptorchidism is associated with increased risk of infertility and testicular cancer. The frequency of INSL3 gene mutations as a cause of cryptorchidism is low.,Function:Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor.,similarity:Belongs to the insulin family.,subunit:Heterodimer of a B chain and an A chain linked by two disulfide bonds.,tissue specificity:Expressed in prenatal and postnatal Leydig cells. Found as well in the corpus luteum, trophoblast, fetal membranes and breast.,

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INSL3 Polyclonal Antibody

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INSL3 Polyclonal Antibody

Product details

Specifications

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