Price range: $268.00 through $328.00
Background:
This gene encodes a member of the inositol 1, 4, 5-trisphosphate [Ins(1, 4, 5)P(3)] 3-kinase family of enzymes that catalyze the phosphorylation of inositol 1, 4, 5-trisphosphate to 1, 3, 4, 5-tetrakisphosphate. The encoded protein is localized to the nucleus and cytoplasm and has both nuclear import and nuclear export activity. Single nucleotide polymorphisms in this gene are associated with Kawasaki disease.[provided by RefSeq, Sep 2009],
| Size | 50μL/100μL |
| Target | InsP 3-kinase C |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 102kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human IP3KC. AA range:221-270 |
| Specificity | InsP 3-kinase C Polyclonal Antibody detects endogenous levels of InsP 3-kinase C protein. |
| Gene Name | ITPKC |
| Protein Name | Inositol-trisphosphate 3-kinase C |
| Other Name | ITPKC; / IP3KC; / Inositol-trisphosphate 3-kinase C; / Inositol 1; / 4,5-trisphosphate 3-kinase C; / IP3 3-kinase C; / IP3K C; / InsP 3-kinase C |
| Species | Human |
| Gene ID | 80271 |
| Uniprot | Q96DU7, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q7TS72 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus . Cytoplasm . Shuttles actively between nucleus and cytoplasm with both nuclear import and nuclear export activity. . |
| Tissue Expression | Highly expressed in pancreas, skeletal muscle, liver, placenta and weakly in kidney and brain. |
| Signaling_pathway | Environmental Information Processing >> Signal transduction >> Calcium signaling pathway |
| Research Areas | >>Inositol phosphate metabolism; / >>Metabolic pathways; / >>Calcium signaling pathway; / >>Phosphatidylinositol signaling system |
| Function | Catalytic activity:ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate.,Disease:Genetic variations in ITPKC influence susceptibility to Kawasaki disease [MIM:611775]; also known as mucocutaneous lymph node syndrome or infantile polyarteritis. Kawasaki disease is an acute, self-limited vasculitis of infants and children characterized by prolonged fever unresponsive to antibiotics, polymorphous skin rash, erythema of the oral mucosa, lips, and tongue, erythema of the palms and soles, bilateral conjunctival injection, and cervical lymphadenopathy. Coronary artery aneurysms develop in 15 to 25% of those left untreated, making Kawasaki disease the leading cause of acquired heart disease among children in developed countries.,enzyme regulation:Activated by calcium/calmodulin. Inhibited by high concentrations of the substrate Ins(1,2,4)P3, and allosterically activated by the product Ins(1,3,4,5)P4.,Function:Can phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate.,similarity:Belongs to the inositol phosphokinase (IPK) family.,subcellular location:Shuttles actively between nucleus and cytoplasm with both nuclear import and nuclear export activity.,tissue specificity:Highly expressed in pancreas, skeletal muscle, liver, placenta and weakly in kidney and brain., |
