Price range: $268.00 through $328.00
Background:
The protein encoded by this gene is a member of the G-protein coupled receptor family 1 and has been shown to be a receptor for prostacyclin. Prostacyclin, the major product of cyclooxygenase in macrovascular endothelium, elicits a potent vasodilation and inhibition of platelet aggregation through binding to this receptor. [provided by RefSeq, Jul 2008],
| Target | IP Receptor |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IF, ELISA, IHC |
| MW(Calculated) | |
| MW(Observed) | 45kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Modification | |
| Recommended Dilution Ratio | WB 1:500-2000; IHC 1:50-300; IF 1:200-1:1000; ELISA 1:2000-20000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Source | |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Purity | |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Prostacyclin Receptor. AA range:198-247 |
| Sequence | |
| Specificity | IP Receptor Polyclonal Antibody detects endogenous levels of IP Receptor protein. |
| Gene Name | PTGIR |
| Protein Name | Prostacyclin receptor |
| Other Name | PTGIR; / PRIPR; / Prostacyclin receptor; / Prostaglandin I2 receptor; / PGI receptor; / PGI2 receptor; / Prostanoid IP receptor |
| Species | Human |
| Gene ID-1 | 5739 |
| Uniprot | P43119, |
| Species.1 | Mouse |
| Gene ID-2 | |
| Uniprot.1 | P43252 |
| Species.2 | |
| Gene ID-3 | |
| Uniprot.2 | |
| Organism-4 | |
| Gene ID-4 | |
| SwissProt-4 | |
| Background | The protein encoded by this gene is a member of the G-protein coupled receptor family 1 and has been shown to be a receptor for prostacyclin. Prostacyclin, the major product of cyclooxygenase in macrovascular endothelium, elicits a potent vasodilation and inhibition of platelet aggregation through binding to this receptor. [provided by RefSeq, Jul 2008], |
| Cellular Localization | Cell membrane; Multi-pass membrane protein. |
| Tissue Expression | Lung,Pancreas,Placenta, |
| Signaling_pathway | Organismal Systems >> Immune system >> Platelet activation;Organismal Systems >> Circulatory system >> Vascular smooth muscle contraction |
| Research Areas | >>Neuroactive ligand-receptor interaction; / >>Vascular smooth muscle contraction; / >>Platelet activation |
| Function | Function:Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase.,PTM:Isoprenylation does not influence ligand binding but is required for efficient coupling to the effectors adenylyl cyclase and phospholipase C.,PTM:Palmitoylation of either Cys-308 or Cys-311 is sufficient to maintain functional coupling to G(s) and signaling.,similarity:Belongs to the G-protein coupled receptor 1 family., |
| RRID |
