Name: IP3KA Polyclonal Antibody
SKU: WP12855
Price: 268 USD
Availability: InStock

IP3KA Polyclonal Antibody

Ucallm_WP12855-50

Price range: $268.00 through $328.00

Size

100μl

50μl

Clear

SKU: WP12855-100

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Product details

Background:

Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1, 4, 5-trisphosphate to Ins(1, 3, 4, 5)P4. The activity of the inositol 1, 4, 5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro.[provided by RefSeq, Apr 2011],

Specifications

Size	50μL/100μL
Target	IP3KA
Reactivity	Human, Mouse, Rat
Applications	WB, ELISA, IHC
MW(Calculated)
MW(Observed)	52kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-2000; IHC 1:50-300; ELISA 1:2000-20000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from human IP3KA. AA range:396-445
Specificity	IP3KA Polyclonal Antibody detects endogenous levels of IP3KA protein.
Gene Name	ITPKA
Protein Name	Inositol-trisphosphate 3-kinase A
Other Name	ITPKA; / Inositol-trisphosphate 3-kinase A; / Inositol 1; / 4,5-trisphosphate 3-kinase A; / IP3 3-kinase A; / IP3K A; / InsP 3-kinase A
Species	Human
Gene ID	3706
Uniprot	P23677,
Species.1	Mouse
Gene ID.1	228550
Uniprot.1	Q8R071,
Species.2	Rat
Gene ID.2	81677
Uniprot.2	P17105
Cellular Localization	Cytoplasm, cytoskeleton .
Tissue Expression	Expressed in brain.
Signaling_pathway	Environmental Information Processing >> Signal transduction >> Calcium signaling pathway
Research Areas	>>Inositol phosphate metabolism; / >>Metabolic pathways; / >>Calcium signaling pathway; / >>Phosphatidylinositol signaling system
Function	Catalytic activity:ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate.,enzyme regulation:IP3K is activated by calmodulin.,similarity:Belongs to the inositol phosphokinase (IPK) family.,