Name: IRS2 Polyclonal Antibody
SKU: WP15792
Price: 268 USD
Availability: InStock

IRS2 Polyclonal Antibody

Ucallm_WP15792-50

Price range: $268.00 through $328.00

Size

100μl

50μl

Clear

SKU: WP15792-100

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Product details

Background:

This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment. [provided by RefSeq, Jul 2008],

Specifications

Size	50μL/100μL
Target	IRS2
Reactivity	Human, Mouse
Applications	WB, ELISA
MW(Calculated)
MW(Observed)	170kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-2000; ELISA 1:10000-20000
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	Synthetic peptide from human protein at AA range: 660-700
Specificity	The antibody detects endogenous IRS2 protein
Gene Name	IRS2
Protein Name	insulin receptor substrate 2
Other Name	IRS2
Species	Human
Gene ID	8660
Uniprot	Q9Y4H2,
Species.1	Mouse
Gene ID.1	384783
Uniprot.1	P81122
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Cytoplasm, cytosol .
Tissue Expression	Blood,Epithelium,Platelet,
Signaling_pathway	Cellular Processes >> Transport and catabolism >> Autophagy - animal;Organismal Systems >> Endocrine system >> Insulin signaling pathway;Organismal Systems >> Endocrine system >> Adipocytokine signaling pathway;Organismal Systems >> Endocrine system >> Growth hormone synthesis, secretion and action;Organismal Systems >> Aging >> Longevity regulating pathway;Organismal Systems >> Aging >> Longevity regulating pathway - multiple species;Human Diseases >> Cancer: overview >> MicroRNAs in cancer;Human Diseases >> Neurodegenerative disease >> Alzheimer disease;Environmental Information Processing >> Signal transduction >> FoxO signaling pathway;Environmental Information Processing >> Signal transduction >> cGMP-PKG signaling pathway;Environmental Information Processing >> Signal transduction >> AMPK signaling pathway
Research Areas	>>cGMP-PKG signaling pathway; / >>FoxO signaling pathway; / >>Autophagy - animal; / >>AMPK signaling pathway; / >>Longevity regulating pathway; / >>Longevity regulating pathway - multiple species; / >>Insulin signaling pathway; / >>Adipocytokine signaling pathway; / >>Regulation of lipolysis in adipocytes; / >>Type II diabetes mellitus; / >>Insulin resistance; / >>Non-alcoholic fatty liver disease; / >>Growth hormone synthesis, secretion and action; / >>Alzheimer disease; / >>MicroRNAs in cancer
Function	Function:May mediate the control of various cellular processes by insulin.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 IRS-type PTB domain.,similarity:Contains 1 PH domain.,