SKU: WP3187 Categories: ,

ITSN2 Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP3187-100
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Product details

Background:

This gene encodes a cytoplasmic protein which contains SH3 domains. This protein is a member of a family of proteins involved in clathrin-mediated endocytosis. Intersectin 2 is thought to regulate the formation of clathrin-coated vesicles and also may function in the induction of T cell antigen receptor (TCR) endocytosis. Alternatively spliced transcript variants have been found for this gene that encode three distinct isoforms. Additional variants have been found but their full length nature has not been determined. [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetITSN2
ReactivityHuman, Mouse
ApplicationsWB, ELISA
MW(Calculated)
MW(Observed)186kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000; ELISA 1:5000-20000
FormulationLiquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from part region of human protein AA range: 1125-1175
SpecificityITSN2 Polyclonal Antibody detects endogenous levels of protein.
Gene NameITSN2 KIAA1256 SH3D1B SWAP
Protein NameIntersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein)
Other Name
SpeciesHuman
Gene ID50618
UniprotQ9NZM3,
Species.1Mouse
Gene ID.1
Uniprot.1Q9Z0R6
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationCytoplasm.
Tissue ExpressionExpressed in melanocytes (PubMed:23999003). Ubiquitous. Isoform 1 is primarily expressed in adult heart and liver.
Signaling_pathway
Research Areas
FunctionAlternative products:Additional isoforms seem to exist,Function:Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles.,miscellaneous:Overexpression results in the inhibition of the transferrin uptake and the blockage of the clathrin-mediated endocytosis.,similarity:Contains 1 C2 domain.,similarity:Contains 1 DH (DBL-homology) domain.,similarity:Contains 1 PH domain.,similarity:Contains 2 EF-hand domains.,similarity:Contains 2 EH domains.,similarity:Contains 5 SH3 domains.,subunit:Belongs to a complex that may contain multimers of ITSN1, ITSN2 and EPS15, and different partners according to the step in the endocytic process.,tissue specificity:Ubiquitous. Isoform 1 is primarily expressed in adult heart and liver.,
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