Product details
Background:
IVNS1ABP rabbit pAb
Ucallm_WP7630-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | IVNS1ABP |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 71kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human IVNS1ABP |
| Specificity | This antibody detects endogenous levels of IVNS1ABP at Human, Mouse |
| Gene Name | IVNS1ABP ARA3 FLARA3 KIAA0850 NS1 NS1BP HSPC068 |
| Protein Name | Influenza virus NS1A-binding protein (NS1-BP) (NS1-binding protein) (Aryl hydrocarbon receptor-associated protein 3) |
| Other Name | |
| Species | Human |
| Gene ID | 10625 |
| Uniprot | Q9Y6Y0, |
| Species.1 | Mouse |
| Gene ID.1 | 117198 |
| Uniprot.1 | Q920Q8 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm . Cytoplasm, cytoskeleton . Nucleus, nucleoplasm . Associated with actin filaments (By similarity). Localization related to speckle domains which correspond to interchromatin granules and are enriched in factors involved in pre-mRNA splicing (PubMed:9696811). Following influenza A virus infection, redistribution from speckles to a more diffuse distribution in the nucleoplasm (PubMed:9696811). . |
| Tissue Expression | |
| Signaling_pathway | |
| Research Areas | |
| Function | Involved in many cell functions, including pre-mRNA splicing, the aryl hydrocarbon receptor (AHR) pathway, F-actin organization and protein ubiquitination. Plays a role in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats (By similarity). Protects cells from cell death induced by actin destabilization (By similarity). Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription . In addition, functions as a negative regulator of BCR(KLHL20) E3 ubiquitin ligase complex to prevent ubiquitin-mediated proteolysis of PML and DAPK1, two tumor suppressors . Inhibits pre-mRNA splicing (in vitro) .; (Microbial infection) Involved in the alternative splicing of influenza A virus M1 mRNA through interaction with HNRNPK, thereby facilitating the generation of viral M2 protein. |
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