Price range: $268.00 through $328.00
Background:
The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. The protein encoded by this gene is one of several ligands that activate Notch and related receptors. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
| Size | 50μL/100μL |
| Target | JAG2 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 136kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | JAG2 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | JAG2 |
| Protein Name | Protein jagged-2 (Jagged2) (hJ2) |
| Other Name | |
| Species | Human |
| Gene ID | 3714 |
| Uniprot | Q9Y219, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q9QYE5, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | P97607 |
| Cellular Localization | Membrane; Single-pass type I membrane protein. |
| Tissue Expression | Expressed in heart, placenta and skeletal muscle and to a lesser extent in pancreas. Very low expression in brain, lung, liver and kidney. |
| Signaling_pathway | Organismal Systems >> Immune system >> Th1 and Th2 cell differentiation;Human Diseases >> Cancer: overview >> Pathways in cancer;Human Diseases >> Cancer: specific types >> Breast cancer;Environmental Information Processing >> Signal transduction >> Notch signaling pathway |
| Research Areas | >>Endocrine resistance; / >>Notch signaling pathway; / >>Th1 and Th2 cell differentiation; / >>Pathways in cancer; / >>Breast cancer |
| Function | Disease:May be associated with Usher syndrome type IA (USHA1A) which describes a congenital sensory deafness associated with retinitis pigmentosa and feeble-mindedness.,Function:Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development.,similarity:Contains 1 DSL domain.,similarity:Contains 1 VWFC domain.,similarity:Contains 16 EGF-like domains.,tissue specificity:Expressed in heart, placenta and skeletal muscle and to a lesser extend in pancreas. Very low expression in brain, lung, liver and kidney., |
