KAISO Polyclonal Antibody
Ucallm_WP2069-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-α2 (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear impor
Specifications
| Size | 50μL/100μL |
| Target | KAISO |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 73kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 100-180 |
| Specificity | KAISO Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | ZBTB33 KAISO ZNF348 |
| Protein Name | Transcriptional regulator Kaiso (Zinc finger and BTB domain-containing protein 33) |
| Other Name | |
| Species | Human |
| Gene ID | 10009 |
| Uniprot | Q86T24, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q8BN78 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus . Cytoplasm . Also cytoplasmic in cells grown at high densities. |
| Tissue Expression | Expressed in vascular endothelium. |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3'. Recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. May contribute to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2.,induction:Induced in vascular endothelium by wounding. This effect is potentiated by prior laminar shear stress, which enhances wound closure.,similarity:Contains 1 BTB (POZ) domain.,similarity:Contains 3 C2H2-type zinc fingers.,subcellular location:Also cytoplasmic in cells grown at high densities.,subunit:Self-associates. Interacts with CTNND2 (By similarity). Interacts with CTNND1, and this interaction inhibits binding to both methylated and non-methylated DNA. Interacts with NCOR1. Interacts with KPNA2/RCH1, which may mediate nuclear import of this protein.,tissue specificity:Expressed in vascular endothelium., |
Please login to post questions
Related products
