Product details
Background:
Kallikrein-6 (Cleaved-Leu22) rabbit pAb
Ucallm_WP0172-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | Kallikrein-6 |
| Reactivity | Human, Rat |
| Applications | WB, ELISA, IHC |
| MW(Calculated) | |
| MW(Observed) | 25kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; IHC 1:50-300; ELISA 1:2000-20000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human Kallikrein-6 (Cleaved-Leu22) |
| Specificity | This antibody detects endogenous levels of Human Kallikrein-6 (Cleaved-Leu22, protein was cleaved amino acid sequence between 21-22 ) |
| Gene Name | KLK6 PRSS18 PRSS9 |
| Protein Name | Kallikrein-6 (Cleaved-Leu22) |
| Other Name | Kallikrein-6; / Neurosin; / Protease M; / SP59; / Serine protease 18; / Serine protease 9; / Zyme |
| Species | Human |
| Gene ID | 5653 |
| Uniprot | Q92876 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Secreted. Nucleus, nucleolus. Cytoplasm. Mitochondrion. Microsome. In brain, detected in the nucleus of glial cells and in the nucleus and cytoplasm of neurons. Detected in the mitochondrial and microsomal fractions of HEK-293 cells and released into the cytoplasm following cell stress. |
| Tissue Expression | In fluids, highest levels found in milk of lactating women followed by cerebrospinal fluid, nipple aspirate fluid and breast cyst fluid. Also found in serum, seminal plasma and some amniotic fluids and breast tumor cytosolic extracts. Not detected in urine. At the tissue level, highest concentrations found in glandular tissues such as salivary glands followed by lung, colon, fallopian tube, placenta, breast, pituitary and kidney. Not detected in skin, spleen, bone, thyroid, heart, ureter, liver, muscle, endometrium, testis, pancreas, seminal vesicle, ovary, adrenals and prostate. In brain, detected in gray matter neurons (at protein level). Colocalizes with pathological inclusions such as Lewy bodies and glial cytoplasmic inclusions. Overexpressed in primary breast tumors but not expressed in metastatic tumors. |
| Signaling_pathway | |
| Research Areas | |
| Function |
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