SKU: WP15290 Categories: ,

Kallistatin Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP15290-100
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Product details

Background:

function:Inhibits human amidolytic and kininogenase activities of tissue kallikrein. Inhibition is achieved by formation of an equimolar, heat- and SDS-stable complex between the inhibitor and the enzyme, and generation of a small C-terminal fragment of the inhibitor due to cleavage at the reactive site by tissue kallikrein., miscellaneous:Heparin blocks kallistatin’s complex formation with tissue kallikrein and abolishes its inhibitory effect on tissue kallikrein’s activity., PTM:The N-terminus is blocked., similarity:Belongs to the serpin family., subunit:Monomer and some homodimers., tissue specificity:Expressed by the liver and secreted in plasma.,

Specifications

Size50μL/100μL
TargetKallistatin
ReactivityHuman
ApplicationsWB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)47kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; IHC: 1:100-300; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human SERPINA4. AA range:161-210
SpecificityKallistatin Polyclonal Antibody detects endogenous levels of Kallistatin protein.
Gene NameSERPINA4
Protein NameKallistatin
Other NameSERPINA4; / KST; / PI4; / Kallistatin; / Kallikrein inhibitor; / Peptidase inhibitor 4; / PI-4; / Serpin A4
SpeciesHuman
Gene ID5267
UniprotP29622
Species.1
Gene ID.1
Uniprot.1
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationSecreted.
Tissue ExpressionExpressed by the liver and secreted in plasma.
Signaling_pathway
Research Areas
FunctionFunction:Inhibits human amidolytic and kininogenase activities of tissue kallikrein. Inhibition is achieved by formation of an equimolar, heat- and SDS-stable complex between the inhibitor and the enzyme, and generation of a small C-terminal fragment of the inhibitor due to cleavage at the reactive site by tissue kallikrein.,miscellaneous:Heparin blocks kallistatin's complex formation with tissue kallikrein and abolishes its inhibitory effect on tissue kallikrein's activity.,PTM:The N-terminus is blocked.,similarity:Belongs to the serpin family.,subunit:Monomer and some homodimers.,tissue specificity:Expressed by the liver and secreted in plasma.,
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