SKU: WP16703 Categories: ,

KCNH4 rabbit pAb

Price range: $268.00 through $328.00

SKU: WP16703-100
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Product details

Background:

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. The gene is brain-specific, and located in the neocortex and the striatum. It may be involved in cellular excitability of restricted neurons in the central nervous system. [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetKCNH4
ReactivityHuman, Rat
ApplicationsWB, ELISA, IHC
MW(Calculated)112kD
MW(Observed)
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000; IHC 1:50-300; ELISA 1:2000-20000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from human KCNH4.AA range:180-250
SpecificityThis antibody detects endogenous levels of KCNH4 at Human/Rat
Gene NameKCNH4
Protein NameKCNH4
Other Name
SpeciesHuman
Gene ID23415
UniprotQ9UQ05,
Species.1
Gene ID.1
Uniprot.1
Species.2Rat
Gene ID.2114032
Uniprot.2Q9R1T9
Cellular LocalizationMembrane; Multi-pass membrane protein.
Tissue ExpressionDetected only in brain, in particular in the telencephalon. Detected in putamen and caudate nucleus, and at lower levels in cerebral cortex, occipital and hippocampus.
Signaling_pathway
Research Areas
FunctionDomain:The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.,Function:Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current, but shows no inactivation. Channel properties may be modulated by cAMP and subunit assembly.,similarity:Belongs to the potassium channel family. H (Eag) subfamily.,similarity:Contains 1 cyclic nucleotide-binding domain.,similarity:Contains 1 PAC (PAS-associated C-terminal) domain.,similarity:Contains 1 PAS (PER-ARNT-SIM) domain.,subunit:The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.,tissue specificity:Detected only in brain, in particular in the telencephalon. Detected in putamen and caudate nucleus, and at lower levels in cerebral cortex, occipital and hippocampus.,
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