KCNK2 rabbit pAb
Ucallm_WP4112-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes one of the members of the two-pore-domain background potassium channel protein family. This type of potassium channel is formed by two homodimers that create a channel that leaks potassium out of the cell to control resting membrane potential. The channel can be opened, however, by certain anesthetics, membrane stretching, intracellular acidosis, and heat. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | KCNK2 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 47kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human KCNK2 AA range: 219-269 |
| Specificity | This antibody detects endogenous levels of KCNK2 at Human/Mouse |
| Gene Name | KCNK2 TREK TREK1 |
| Protein Name | KCNK2 |
| Other Name | |
| Species | Human |
| Gene ID | 3776 |
| Uniprot | O95069, |
| Species.1 | Mouse |
| Gene ID.1 | 16526 |
| Uniprot.1 | P97438 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | [Isoform 1]: Cell membrane; Multi-pass membrane protein .; [Isoform 2]: Cell membrane; Multi-pass membrane protein .; [Isoform 4]: Endoplasmic reticulum membrane; Multi-pass membrane protein . |
| Tissue Expression | Isoform 4 is detected in kidney, adrenal gland and brain where it is preferentially expressed in the amygdala but not found in thalamus, hypothalamus, hippocampus or substantia nigra. |
| Signaling_pathway | Organismal Systems >> Circulatory system >> Adrenergic signaling in cardiomyocytes;Environmental Information Processing >> Signal transduction >> cAMP signaling pathway |
| Research Areas | >>Cortisol synthesis and secretion; / >>Cushing syndrome; / >>Gastric acid secretion |
| Function | Function:Outward rectifying potassium channel.,miscellaneous:Activated by volatile general anesthetics such as chloroform, halothane and isoflurane.,similarity:Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.,subunit:Homodimer ., |
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