KCNK4 (TRAAK) Polyclonal Antibody
Ucallm_WP5844-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a member of the TWIK-related arachidonic acid-stimulated two pore potassium channel subfamily. The encoded protein homodimerizes and functions as an outwardly rectifying channel. This channel is regulated by polyunsaturated fatty acids, temperature and mechanical deformation of the lipid membrane. This protein is expressed primarily in neural tissues and may be involved in regulating the noxious input threshold in dorsal root ganglia neurons. Alternate splicing results in multiple transcript variants. Naturally occurring read-through transcripts also exist between this gene and the downstream testis expressed 40 (TEX40) gene, as represented in GeneID: 106780802. [provided by RefSeq, Nov 2015],
Specifications
| Size | 50μL/100μL |
| Target | KCNK4 |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC, IF |
| MW(Calculated) | |
| MW(Observed) | 43kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:100-200; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthetic Peptide of KCNK4 (TRAAK) AA range: 38-88 |
| Specificity | KCNK4(TRAAK) protein(A238) detects endogenous levels of KCNK4(TRAAK) |
| Gene Name | KCNK4 |
| Protein Name | Potassium channel subfamily K member 4 (TWIK-related arachidonic acid-stimulated potassium channel protein) (TRAAK) (Two pore potassium channel KT4.1) (Two pore K(+) channel KT4.1) |
| Other Name | KCNK4; / TRAAK; / Potassium channel subfamily K member 4; / TWIK-related arachidonic acid-stimulated potassium channel protein; / TRAAK; / Two pore potassium channel KT4.1; / Two pore K; / +; / channel KT4.1 |
| Species | Human |
| Gene ID | 50801 |
| Uniprot | Q9NYG8, |
| Species.1 | Mouse |
| Gene ID.1 | 16528 |
| Uniprot.1 | O88454 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Multi-pass membrane protein . |
| Tissue Expression | Brain,Frontal cortex, |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Voltage insensitive, instantaneous, outwardly rectifying potassium channel. Outward rectification is reversed at high external K(+) concentrations.,similarity:Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.,subunit:Homodimer ., |
Please login to post questions
Related products
