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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/KCNN4 (SK4) Polyclonal Antibody
SKU: WP5840 Categories: ,

KCNN4 (SK4) Polyclonal Antibody

Ucallm_WP5840-50

Price range: $268.00 through $328.00

SKU: WP5840-100
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Product details

Background:

potassium calcium-activated channel subfamily N member 4(KCNN4) Homo sapiens The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily. [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetKCNN4
ReactivityHuman, Mouse, Rat
ApplicationsWB, IHC, IF
MW(Calculated)
MW(Observed)50kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:1000-2000; IHC 1:50-100; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthetic Peptide of KCNN4 (SK4) AA range: 177-227
SpecificityKCNN4(SK4) protein(A247) detects endogenous levels of KCNN4(SK4)
Gene NameKCNN4
Protein NameIntermediate conductance calcium-activated potassium channel protein 4 (SK4) (SKCa 4) (SKCa4) (IKCa1) (IK1) (KCa3.1) (KCa4) (Putative Gardos channel)
Other NameKCNN4; / IK1; / IKCA1; / KCA4; / SK4; / Intermediate conductance calcium-activated potassium channel protein 4; / SK4; / SKCa 4; / SKCa4; / IKCa1; / IK1; / KCa3.1; / KCa4; / Putative Gardos channel
SpeciesHuman
Gene ID3783
UniprotO15554,
Species.1Mouse
Gene ID.116534
Uniprot.1O89109,
Species.2Rat
Gene ID.2
Uniprot.2Q9QYW1
Cellular LocalizationCell membrane; Multi-pass membrane protein .
Tissue ExpressionWidely expressed in non-excitable tissues.
Signaling_pathwayOrganismal Systems >> Endocrine system >> Insulin secretion
Research Areas>>Insulin secretion; / >>GnRH secretion; / >>Salivary secretion; / >>Protein digestion and absorption
FunctionFunction:Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin.,induction:Up-regulated by phorbol myristate acetate (PMA) and phytohemagglutinin (PHA) in T-cells.,similarity:Belongs to the potassium channel KCNN family.,subunit:Heterotetramer of potassium channel proteins (Probable). Interacts with MTMR6.,tissue specificity:Widely expressed in non-excitable tissues.,
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