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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/KDM5A Polyclonal Antibody
SKU: WP0666 Categories: ,

KDM5A Polyclonal Antibody

Ucallm_WP0666-50

Price range: $268.00 through $328.00

SKU: WP0666-100
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Product details

Background:

This gene encodes a member of the Jumonji, AT-rich interactive domain 1 (JARID1) histone demethylase protein family. The encoded protein plays a role in gene regulation through the histone code by specifically demethylating lysine 4 of histone H3. The encoded protein interacts with many other proteins, including retinoblastoma protein, and is implicated in the transcriptional regulation of Hox genes and cytokines. This gene may play a role in tumor progression. [provided by RefSeq, Aug 2013],

Specifications

Size50μL/100μL
TargetKDM5A
ReactivityHuman, Mouse
ApplicationsWB, ELISA
MW(Calculated)
MW(Observed)185kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000; ELISA 1:5000-20000
FormulationLiquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from human protein . at AA range: 720-800
SpecificityKDM5A Polyclonal Antibody detects endogenous levels of protein.
Gene NameKDM5A JARID1A RBBP2 RBP2
Protein NameLysine-specific demethylase 5A (Histone demethylase JARID1A) (Jumonji/ARID domain-containing protein 1A) (Retinoblastoma-binding protein 2) (RBBP-2)
Other Name
SpeciesHuman
Gene ID5927
UniprotP29375,
Species.1Mouse
Gene ID.1
Uniprot.1Q3UXZ9
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationNucleus, nucleolus . Nucleus . Occupies promoters of genes involved in RNA metabolism and mitochondrial function. .
Tissue ExpressionEpithelium,Eye,Testis,
Signaling_pathway
Research Areas
Functioncofactor:Fe(2+).,Function:Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May stimulate transcription mediated by nuclear receptors. May be involved in transcriptional regulation of Hox proteins during cell differentiation. May participate in transcriptional repression of cytokines such as CXCL12.,similarity:Belongs to the JARID1 histone demethylase family.,similarity:Contains 1 ARID domain.,similarity:Contains 1 JmjC domain.,similarity:Contains 1 JmjN domain.,similarity:Contains 3 PHD-type zinc fingers.,subunit:Interacts with the viral protein-binding domain of RB1. Interacts with ESR1, MYC, MYCN and LMO2.,
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