Price range: $268.00 through $328.00
Background:
Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene encodes an epithelial keratin that is expressed in the skin and eccrine sweat glands. The type II keratins are clustered in a region of chromosome 12q13.[provided by RefSeq, Jun 2009],
| Size | 50μL/100μL |
| Target | Keratin 77 |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC, IF, WB |
| MW(Calculated) | |
| MW(Observed) | 61kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:50-200; WB 1:500-2000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human Keratin 77 |
| Specificity | This antibody detects endogenous levels of human Keratin 77 |
| Gene Name | KRT77 KRT1B |
| Protein Name | Keratin 77 |
| Other Name | Keratin, type II cytoskeletal 1b; / Cytokeratin-1B; / CK-1B; / Keratin-77; / K77; / Type-II keratin Kb39 |
| Species | Human |
| Gene ID | 374454 |
| Uniprot | Q7Z794 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | cytoskeleton,intermediate filament,keratin filament,extracellular exosome, |
| Tissue Expression | Expressed exclusively in skin. |
| Signaling_pathway | |
| Research Areas | |
| Function | miscellaneous:There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).,PTM:Undergoes deimination of some arginine residues (citrullination).,similarity:Belongs to the intermediate filament family.,tissue specificity:Expressed exclusively in skin., |
