KIF5A rabbit pAb
Ucallm_WP16888-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a member of the kinesin family of proteins. Members of this family are part of a multisubunit complex that functions as a microtubule motor in intracellular organelle transport. Mutations in this gene cause autosomal dominant spastic paraplegia 10. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | KIF5A |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA, IHC |
| MW(Calculated) | 114kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; IHC 1:50-300; ELISA 1:2000-20000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human KIF5A AA range: 213-263 |
| Specificity | This antibody detects endogenous levels of KIF5A at Human/Mouse/Rat |
| Gene Name | KIF5A NKHC1 |
| Protein Name | KIF5A |
| Other Name | |
| Species | Human |
| Gene ID | 3798 |
| Uniprot | Q12840, |
| Species.1 | Mouse |
| Gene ID.1 | 16572 |
| Uniprot.1 | P33175, |
| Species.2 | Rat |
| Gene ID.2 | 314906 |
| Uniprot.2 | Q6QLM7 |
| Cellular Localization | Cytoplasm, perinuclear region . Cytoplasm, cytoskeleton . Perikaryon . Concentrated in the cell body of the neurons, particularly in the perinuclear region. . |
| Tissue Expression | Distributed throughout the CNS but is highly enriched in subsets of neurons. |
| Signaling_pathway | Organismal Systems >> Nervous system >> Dopaminergic synapse;Human Diseases >> Cancer: specific types >> Non-small cell lung cancer;Human Diseases >> Neurodegenerative disease >> Alzheimer disease;Human Diseases >> Neurodegenerative disease >> Parkinson disease;Human Diseases >> Neurodegenerative disease >> Amyotrophic lateral sclerosis;Human Diseases >> Neurodegenerative disease >> Huntington disease;Human Diseases >> Neurodegenerative disease >> Prion disease;Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases |
| Research Areas | >>Endocytosis; / >>Dopaminergic synapse; / >>Alzheimer disease; / >>Parkinson disease; / >>Amyotrophic lateral sclerosis; / >>Huntington disease; / >>Prion disease; / >>Pathways of neurodegeneration - multiple diseases; / >>Salmonella infection; / >>Non-small cell lung cancer |
| Function | Disease:Defects in KIF5A are the cause of spastic paraplegia type 10 (SPG10) [MIM:604187]. SPG10 is a form of autosomal dominant hereditary spastic paraplegia (AD-HSP). HSP is a group of inherited degenerative spinal cord disorders characterized by a slow, gradual, progressive weakness and spasticity (stiffness) of the legs. Rate of progression and the severity of symptoms is quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body.,Domain:Composed of three structural domains: a large globular N-terminal domain which is responsible for the motor activity of kinesin (it hydrolyzes ATP and binds microtubule), a central alpha-helical coiled coil domain that mediates the heavy chain dimerization; and a small globular C-terminal domain which interacts with other proteins (such as the kinesin light chains), vesicles and membranous organelles.,Function:Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL).,similarity:Belongs to the kinesin-like protein family. Kinesin subfamily.,similarity:Contains 1 kinesin-motor domain.,subcellular location:Concentrated in the cell body of the neurons, particularly in the perinuclear region.,subunit:Oligomer composed of two heavy chains and two light chains. Interacts with GRIP1.,tissue specificity:Distributed throughout the CNS but is highly enriched in subsets of neurons., |
Please login to post questions
Related products
