Product details
Background:
KINH rabbit pAb
Ucallm_WP3673-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | KINH |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | |
| MW(Observed) | 105kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human KINH AA range: 64-114 |
| Specificity | This antibody detects endogenous levels of KINH at Human/Mouse/Rat |
| Gene Name | KIF5B KNS KNS1 |
| Protein Name | KINH |
| Other Name | Kinesin-1 heavy chain; / Conventional kinesin heavy chain; / Ubiquitous kinesin heavy chain; / UKHC |
| Species | Human |
| Gene ID | 3799 |
| Uniprot | P33176, |
| Species.1 | Mouse |
| Gene ID.1 | 16573 |
| Uniprot.1 | Q61768, |
| Species.2 | Rat |
| Gene ID.2 | 117550 |
| Uniprot.2 | Q2PQA9 |
| Cellular Localization | Cytoplasm, cytoskeleton . Cytolytic granule membrane . Lysosome membrane; Peripheral membrane protein; Cytoplasmic side . Uniformly distributed between soma and neurites in hippocampal neurons. . |
| Tissue Expression | Muscle,Placenta,Uterus, |
| Signaling_pathway | Organismal Systems >> Nervous system >> Dopaminergic synapse;Human Diseases >> Cancer: specific types >> Non-small cell lung cancer;Human Diseases >> Neurodegenerative disease >> Alzheimer disease;Human Diseases >> Neurodegenerative disease >> Parkinson disease;Human Diseases >> Neurodegenerative disease >> Amyotrophic lateral sclerosis;Human Diseases >> Neurodegenerative disease >> Huntington disease;Human Diseases >> Neurodegenerative disease >> Prion disease;Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases |
| Research Areas | >>Endocytosis; / >>Dopaminergic synapse; / >>Alzheimer disease; / >>Parkinson disease; / >>Amyotrophic lateral sclerosis; / >>Huntington disease; / >>Prion disease; / >>Pathways of neurodegeneration - multiple diseases; / >>Salmonella infection; / >>Non-small cell lung cancer |
| Function | Domain:Composed of three structural domains: a large globular N-terminal domain which is responsible for the motor activity of kinesin (it hydrolyzes ATP and binds microtubule), a central alpha-helical coiled coil domain that mediates the heavy chain dimerization; and a small globular C-terminal domain which interacts with other proteins (such as the kinesin light chains), vesicles and membranous organelles.,Function:Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes.,similarity:Belongs to the kinesin-like protein family.,similarity:Belongs to the kinesin-like protein family. Kinesin subfamily.,similarity:Contains 1 kinesin-motor domain.,subcellular location:Uniformly distributed between soma and neurites in hippocampal neurons.,subunit:Oligomer composed of two heavy chains and two light chains. Interacts with GRIP1 (By similarity). Interacts with SYBU. Interacts with JAKMIP1., |
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