SKU: WP12927 Categories: ,

KIR3.4 Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP12927-100
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Product details

Background:

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. It may associate with two other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex. [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetKIR3.4
ReactivityHuman, Mouse, Rat
ApplicationsWB, IHC, IF
MW(Calculated)
MW(Observed)48kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000; IHC 1:50-300; IF 1:200-1:1000; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from human KCNJ5. AA range:370-419
SpecificityKIR3.4 Polyclonal Antibody detects endogenous levels of KIR3.4 protein.
Gene NameKCNJ5
Protein NameG protein-activated inward rectifier potassium channel 4
Other NameKCNJ5; / GIRK4; / G protein-activated inward rectifier potassium channel 4; / GIRK-4; / Cardiac inward rectifier; / CIR; / Heart KATP channel; / Inward rectifier K; / +; / channel Kir3.4; / IRK-4; / KATP-1; / Potassium channel; / inwardly rectifying subfamily J membe
SpeciesHuman
Gene ID3762
UniprotP48544,
Species.1Mouse
Gene ID.1
Uniprot.1P48545
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationMembrane; Multi-pass membrane protein .
Tissue ExpressionIslets, exocrine pancreas and heart. Expressed in the adrenal cortex, particularly the zona glomerulosa.
Signaling_pathwayOrganismal Systems >> Endocrine system >> Estrogen signaling pathway;Organismal Systems >> Endocrine system >> Oxytocin signaling pathway;Organismal Systems >> Endocrine system >> Aldosterone synthesis and secretion;Organismal Systems >> Nervous system >> Dopaminergic synapse
Research Areas>>Circadian entrainment; / >>Retrograde endocannabinoid signaling; / >>Serotonergic synapse; / >>Dopaminergic synapse; / >>Estrogen signaling pathway; / >>Oxytocin signaling pathway; / >>Aldosterone synthesis and secretion; / >>GnRH secretion; / >>Morphine addiction
FunctionFunction:This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium.,similarity:Belongs to the inward rectifier-type potassium channel family.,subunit:May associate with GIRK1 and GIRK2 to form a G-protein-activated heteromultimer pore-forming unit. The resulting inward current is much larger.,tissue specificity:Islets, exocrine pancreas and heart.,
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