Price range: $268.00 through $328.00
Background:
NEPH1 is a member of the nephrin-like protein family, which includes NEPH2 (MIM 607761) and NEPH3 (MIM 607762). The cytoplasmic domains of these proteins interact with the C terminus of podocin (NPHS2; MIM 604766), and the genes are expressed in kidney podocytes, cells involved in ensuring size- and charge-selective ultrafiltration (Sellin et al., 2003 [PubMed 12424224]).[supplied by OMIM, Mar 2008],
| Size | 50μL/100μL |
| Target | KIRR1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 83kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein AA range: 166-216 |
| Specificity | KIRR1 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | KIRREL KIRREL1 NEPH1 |
| Protein Name | Kin of IRRE-like protein 1 (Kin of irregular chiasm-like protein 1) (Nephrin-like protein 1) |
| Other Name | |
| Species | Human |
| Gene ID | 55243 |
| Uniprot | Q96J84, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q80W68, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | Q6X936 |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein . Predominantly located at podocyte slit diaphragm. |
| Tissue Expression | Abundantly expressed in kidney. Specifically expressed in podocytes of kidney glomeruli. |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Plays a significant role in the normal development and function of the glomerular permeability. Signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1.,PTM:Phosphorylation probably regulates the interaction with NSH2.,similarity:Belongs to the immunoglobulin superfamily.,similarity:Contains 5 Ig-like C2-type (immunoglobulin-like) domains.,subcellular location:Predominantly located at podocyte slit diaphragm.,subunit:Interacts with NPHS1/nephrin, TJP1/ZO-1 and C-terminus of NPHS2/podocin.,tissue specificity:Abundantly expressed in kidney. Specifically expressed in podocytes of kidney glomeruli., |
