SKU: WP16627 Categories: ,

KRA13 rabbit pAb

Price range: $268.00 through $328.00

SKU: WP16627-100
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Product details

Background:

This protein is a member of the keratin-associated protein (KAP) family. The KAP proteins form a matrix of keratin intermediate filaments which contribute to the structure of hair fibers. KAP family members appear to have unique, family-specific amino- and carboxyl-terminal regions and are subdivided into three multi-gene families according to amino acid composition: the high sulfur, the ultrahigh sulfur, and the high tyrosine/glycine KAPs. This protein is a member of the high sulfur KAP family and the gene is localized to a cluster of KAPs at 17q12-q21. [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetKRA13
ReactivityHuman
ApplicationsWB, IHC
MW(Calculated)19kD
MW(Observed)
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000; IHC 1:50-300 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from human KRA13 AA range: 95-145
SpecificityThis antibody detects endogenous levels of KRA13 at Human
Gene NameKRTAP1-3 B2B KAP1.2 KAP1.3 KAP1.8 KAP1.9 KRATP1.9 KRTAP1.8
Protein NameKRA13
Other Name
SpeciesHuman
Gene ID81850
UniprotQ8IUG1
Species.1
Gene ID.1
Uniprot.1
Species.2
Gene ID.2
Uniprot.2
Cellular Localizationkeratin filament,
Tissue ExpressionExpressed in the middle/upper portions of the hair cortex, in the region termed the keratogenous zone.
Signaling_pathway
Research Areas
FunctionFunction:In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.,similarity:Belongs to the KRTAP type 1 family.,subunit:Interacts with hair keratins.,tissue specificity:Expressed in the middle/upper portions of the hair cortex, in the region termed the keratogenous zone.,
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