SKU: WP12955 Categories: ,

KV3.1 Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP12955-100
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Product details

Background:

This gene encodes a member of a family of integral membrane proteins that mediate the voltage-dependent potassium ion permeability of excitable membranes. Alternative splicing is thought to result in two transcript variants encoding isoforms that differ at their C-termini. These isoforms have had conflicting names in the literature: the longer isoform has been called both "b" and "alpha", while the shorter isoform has been called both "a" and "beta" (PMIDs 1432046, 12091563). [provided by RefSeq, Oct 2014],

Specifications

Size50μL/100μL
TargetKV3.1
ReactivityHuman, Mouse, Rat
ApplicationsWB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)60kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from KV3.1 . at AA range: 190-270
SpecificityKV3.1 Polyclonal Antibody detects endogenous levels of KV3.1 protein.
Gene NameKCNC1
Protein NamePotassium voltage-gated channel subfamily C member 1
Other NameKCNC1; / Potassium voltage-gated channel subfamily C member 1; / NGK2; / Voltage-gated potassium channel subunit Kv3.1; / Voltage-gated potassium channel subunit Kv4
SpeciesHuman
Gene ID3746
UniprotP48547,
Species.1Mouse
Gene ID.116502
Uniprot.1P15388,
Species.2Rat
Gene ID.225327
Uniprot.2P25122
Cellular LocalizationCell membrane; Multi-pass membrane protein . Cell projection, axon . Cell junction, synapse, presynaptic cell membrane . Localizes in parallel fiber membranes, distributed on the perisynaptic and extrasynaptic membranes away from the active zones. .
Tissue ExpressionPCR rescued clones,
Signaling_pathway
Research Areas
FunctionDomain:The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.,Domain:The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.,Function:Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.,similarity:Belongs to the potassium channel family. C (Shaw) subfamily.,subunit:Heteromultimer with KCNG3, KCNG4 and KCNV2.,
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