KV3.1 Polyclonal Antibody
Ucallm_WP12955-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a member of a family of integral membrane proteins that mediate the voltage-dependent potassium ion permeability of excitable membranes. Alternative splicing is thought to result in two transcript variants encoding isoforms that differ at their C-termini. These isoforms have had conflicting names in the literature: the longer isoform has been called both "b" and "alpha", while the shorter isoform has been called both "a" and "beta" (PMIDs 1432046, 12091563). [provided by RefSeq, Oct 2014],
Specifications
| Size | 50μL/100μL |
| Target | KV3.1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 60kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from KV3.1 . at AA range: 190-270 |
| Specificity | KV3.1 Polyclonal Antibody detects endogenous levels of KV3.1 protein. |
| Gene Name | KCNC1 |
| Protein Name | Potassium voltage-gated channel subfamily C member 1 |
| Other Name | KCNC1; / Potassium voltage-gated channel subfamily C member 1; / NGK2; / Voltage-gated potassium channel subunit Kv3.1; / Voltage-gated potassium channel subunit Kv4 |
| Species | Human |
| Gene ID | 3746 |
| Uniprot | P48547, |
| Species.1 | Mouse |
| Gene ID.1 | 16502 |
| Uniprot.1 | P15388, |
| Species.2 | Rat |
| Gene ID.2 | 25327 |
| Uniprot.2 | P25122 |
| Cellular Localization | Cell membrane; Multi-pass membrane protein . Cell projection, axon . Cell junction, synapse, presynaptic cell membrane . Localizes in parallel fiber membranes, distributed on the perisynaptic and extrasynaptic membranes away from the active zones. . |
| Tissue Expression | PCR rescued clones, |
| Signaling_pathway | |
| Research Areas | |
| Function | Domain:The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.,Domain:The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.,Function:Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.,similarity:Belongs to the potassium channel family. C (Shaw) subfamily.,subunit:Heteromultimer with KCNG3, KCNG4 and KCNV2., |
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