Name: Lamin B2 mouse mAb
SKU: WM0760
Price: 268 USD
Availability: InStock

Lamin B2 mouse mAb

Ucallm_WM0760-50

Price range: $268.00 through $328.00

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SKU: WM0760-50

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Product details

Background:
lamin B2(LMNB2) Homo sapiens This gene encodes a B type nuclear lamin. The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Mutations in this gene are associated with acquired partial lipodystrophy. [provided by RefSeq, May 2012],

Specifications

Size	50μL/100μL
Target	Lamin B2
Reactivity	Human, Mouse
Applications	WB
MW(Calculated)
MW(Observed)	68kD
Host Species	Mouse
Isotype
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	8B5
Immunogen	Recombinant human Lamin B2 protein.
Specificity	This antibody detects endogenous levels of Lamin B2 and does not cross-react with related proteins.
Gene Name	Lamin B2
Protein Name
Other Name	LAMB 2; / LAMB2; / Lamin-B2; / LMN 2; / LMN B2; / LMN2; / LMNB 2; / LMNB2; / LMNB2_HUMAN; / MGC2721; / RGD1563803.
Species	Human
Gene ID	84823
Uniprot	Q03252,
Species.1	Mouse
Gene ID.1
Uniprot.1	P21619
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Nucleus lamina .
Tissue Expression	Epithelium,Fetal brain cortex,Muscle,
Signaling_pathway	Cellular Processes >> Cell growth and death >> Apoptosis
Research Areas	>>Apoptosis
Function	Disease:Defects in LMNB2 are a cause of partial acquired lipodystrophy (APL) [MIM:608709]; also called Barraquer-Simons syndrome. APL is a rare childhood disease characterized by loss of subcutaneous fat from the face and trunk. Fat deposition on the pelvic girdle and lower limbs is normal or excessive. Most frequently, onset between 5 and 15 years of age. Most affected subjects are females and some show no other abnormality, but many develop glomerulonephritis, diabetes mellitus, hyperlipidaemia, and complement deficiency. Mental retardation in some cases. APL is a sporadic disorder of unknown aetiology.,Function:Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.,miscellaneous:The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively.,PTM:B-type lamins undergo a series of modifications, such as farnesylation and phosphorylation. Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin associations.,similarity:Belongs to the intermediate filament family.,subunit:Interacts with TMEM43.,

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Lamin B2 mouse mAb

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Lamin B2 mouse mAb

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