Laminin α-1 Polyclonal Antibody
Ucallm_WP12965-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes one of the alpha 1 subunits of laminin. The laminins are a family of extracellular matrix glycoproteins that have a heterotrimeric structure consisting of an alpha, beta and gamma chain. These proteins make up a major component of the basement membrane and have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Mutations in this gene may be associated with Poretti-Boltshauser syndrome. [provided by RefSeq, Sep 2014],
Specifications
| Size | 50μL/100μL |
| Target | Laminin α-1 |
| Reactivity | Human, Mouse |
| Applications | WB, IF, ELISA, IHC |
| MW(Calculated) | 337kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; IHC 1:50-300; IF 1:200-1:1000; ELISA 1:2000-20000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human LAMA1. AA range:2501-2550 |
| Specificity | Laminin α-1 Polyclonal Antibody detects endogenous levels of Laminin α-1 protein. |
| Gene Name | LAMA1 |
| Protein Name | Laminin subunit alpha-1 |
| Other Name | LAMA1; / LAMA; / Laminin subunit alpha-1; / Laminin A chain; / Laminin-1 subunit alpha; / Laminin-3 subunit alpha; / S-laminin subunit alpha; / S-LAM alpha |
| Species | Human |
| Gene ID | 284217 |
| Uniprot | P25391, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P19137 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Secreted, extracellular space, extracellular matrix, basement membrane. Major component. |
| Tissue Expression | Liver,Placenta,Skin, |
| Signaling_pathway | Cellular Processes >> Cellular community - eukaryotes >> Focal adhesion;Human Diseases >> Cancer: overview >> Pathways in cancer;Human Diseases >> Cancer: specific types >> Small cell lung cancer;Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway;Environmental Information Processing >> Signaling molecules and interaction >> ECM-receptor interaction |
| Research Areas | >>PI3K-Akt signaling pathway; / >>Focal adhesion; / >>ECM-receptor interaction; / >>Toxoplasmosis; / >>Amoebiasis; / >>Human papillomavirus infection; / >>Pathways in cancer; / >>Small cell lung cancer; / >>Hypertrophic cardiomyopathy; / >>Arrhythmogenic right ventricular cardiomyopathy; / >>Dilated cardiomyopathy; / >>Viral myocarditis |
| Function | Domain:Domains VI, IV and G are globular.,Domain:The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure.,Function:Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.,similarity:Contains 1 laminin N-terminal domain.,similarity:Contains 17 laminin EGF-like domains.,similarity:Contains 2 laminin IV type A domains.,similarity:Contains 5 laminin G-like domains.,subcellular location:Major component.,subunit:Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Alpha-1 is a subunit of laminin-1 (EHS laminin) and laminin-3 (S-laminin)., |
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