Name: Laminin β-2 Polyclonal Antibody
SKU: WP12970
Price: 268 USD
Availability: InStock

Product details

Background:

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological func

Specifications

Size	50μL/100μL
Target	Laminin β-2
Reactivity	Human, Mouse, Rat
Applications	WB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)	210kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from human LAMB2. AA range:61-110
Specificity	Laminin β-2 Polyclonal Antibody detects endogenous levels of Laminin β-2 protein.
Gene Name	LAMB2
Protein Name	Laminin subunit beta-2
Other Name	LAMB2; / LAMS; / Laminin subunit beta-2; / Laminin B1s chain; / Laminin-11 subunit beta; / Laminin-14 subunit beta; / Laminin-15 subunit beta; / Laminin-3 subunit beta; / Laminin-4 subunit beta; / Laminin-7 subunit beta; / Laminin-9 subunit beta; / S-laminin sub
Species	Human
Gene ID	3913
Uniprot	P55268,
Species.1	Mouse
Gene ID.1	16779
Uniprot.1	Q61292,
Species.2	Rat
Gene ID.2	25473
Uniprot.2	P15800
Cellular Localization	Secreted, extracellular space, extracellular matrix, basement membrane. S-laminin is concentrated in the synaptic cleft of the neuromuscular junction.
Tissue Expression	Liver,Placenta,Uterus,
Signaling_pathway	Cellular Processes >> Cellular community - eukaryotes >> Focal adhesion;Human Diseases >> Cancer: overview >> Pathways in cancer;Human Diseases >> Cancer: specific types >> Small cell lung cancer;Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway;Environmental Information Processing >> Signaling molecules and interaction >> ECM-receptor interaction
Research Areas	>>PI3K-Akt signaling pathway; / >>Focal adhesion; / >>ECM-receptor interaction; / >>Toxoplasmosis; / >>Amoebiasis; / >>Human papillomavirus infection; / >>Pathways in cancer; / >>Small cell lung cancer
Function	Disease:Defects in LAMB2 are a cause of congenital nephrotic syndrome [MIM:609049]. Congenital nephrotic syndrome constitutes a heterogeneous group of conditions having in common the disruption of normal glomerular permselectivity. Congenital nephrotic syndrome due to LAMB2 mutations may be associated with ocular abnormalities.,Disease:Defects in LAMB2 are the cause of Pierson syndrome [MIM:609049]; also known as microcoria-congenital nephrotic syndrome. Pierson syndrome is characterized by nephrotic syndrome with neonatal onset, diffuse mesangial sclerosis and eye abnormalities with microcoria as the leading clinical feature. Death usually occurs within the first weeks of life. Disease severity depends on the mutation type: nontruncating LAMB2 mutations may display variable phenotypes ranging from a milder variant of Pierson syndrome to isolated congenital nephrotic syndrome.,Domain:Domains VI and IV are globular.,Domain:The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure.,Function:Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.,similarity:Contains 1 laminin IV type B domain.,similarity:Contains 1 laminin N-terminal domain.,similarity:Contains 13 laminin EGF-like domains.,subcellular location:S-laminin is concentrated in the synaptic cleft of the neuromuscular junction.,subunit:Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Beta-2 is a subunit of laminin-3 (S-laminin), laminin-4 (S-merosin), and laminin-7 (KS-laminin).,

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Laminin β-2 Polyclonal Antibody

Product details

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Laminin β-2 Polyclonal Antibody

Product details

Specifications

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