Product details
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LAPTM4B rabbit pAb
Ucallm_WP6319-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | LAPTM4B |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 35kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human LAPTM4B |
| Specificity | This antibody detects endogenous levels of LAPTM4B at Human, Mouse,Rat |
| Gene Name | LAPTM4B PSEC0001 |
| Protein Name | Lysosomal-associated transmembrane protein 4B (Lysosome-associated transmembrane protein 4-beta) |
| Other Name | |
| Species | Human |
| Gene ID | 55353 |
| Uniprot | Q86VI4, |
| Species.1 | Mouse |
| Gene ID.1 | 114128 |
| Uniprot.1 | Q91XQ6, |
| Species.2 | Rat |
| Gene ID.2 | 315047 |
| Uniprot.2 | Q5U1W4 |
| Cellular Localization | Endomembrane system; Multi-pass membrane protein . Late endosome membrane . Cell membrane . Cell projection . Lysosome membrane . Endosome membrane. Endosome, multivesicular body membrane . Endosome, multivesicular body lumen . |
| Tissue Expression | |
| Signaling_pathway | Cellular Processes >> Transport and catabolism >> Lysosome |
| Research Areas | |
| Function | Required for optimal lysosomal function . Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation . Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTORC1 activation . Plays a role as negative regulator of TGFB1 production in regulatory T cells . Binds ceramide and facilitates its exit from late endosome in order to control cell death pathways . |
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