Latrophilin-1 Polyclonal Antibody
Ucallm_WP12982-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Latrophilin-1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Oct 2008],
Specifications
| Size | 50μL/100μL |
| Target | Latrophilin-1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IF, ELISA, IHC |
| MW(Calculated) | 163kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; IHC 1:50-300; IF 1:200-1:1000; ELISA 1:2000-20000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human LPHN1. AA range:561-610 |
| Specificity | Latrophilin-1 Polyclonal Antibody detects endogenous levels of Latrophilin-1 protein. |
| Gene Name | LPHN1 |
| Protein Name | Latrophilin-1 |
| Other Name | LPHN1; / KIAA0821; / LEC2; / Latrophilin-1; / Calcium-independent alpha-latrotoxin receptor 1; / CIRL-1; / Lectomedin-2 |
| Species | Human |
| Gene ID | 22859 |
| Uniprot | O94910, |
| Species.1 | Mouse |
| Gene ID.1 | 330814 |
| Uniprot.1 | Q80TR1, |
| Species.2 | Rat |
| Gene ID.2 | 65096 |
| Uniprot.2 | O88917 |
| Cellular Localization | Cell membrane; Multi-pass membrane protein. Cell projection, axon . Cell projection, growth cone . Cell junction, synapse . Cell junction, synapse, presynaptic cell membrane . Cell junction, synapse, synaptosome . Colocalizes with TENM2 on the cell surface, across intercellular junctions and on nerve terminals near synaptic clefts. . |
| Tissue Expression | Brain,Lung,T-cell,Whole embryo, |
| Signaling_pathway | |
| Research Areas | |
| Function | Domain:The extracellular domain coupled to the a single transmembrane region are sufficient for full responsiveness to alpha-latrotoxin.,Function:Calcium-independent receptor of high affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor propably implicated in the regulation of exocytosis.,PTM:Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit. This proteolytic processing takes place early in the biosynthetic pathway, either in the endoplasmic reticulum or in the early compartment of the Golgi apparatus.,similarity:Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.,similarity:Contains 1 GPS domain.,similarity:Contains 1 olfactomedin-like domain.,similarity:Contains 1 SUEL-type lectin domain.,subunit:Forms a heterodimer, consisting of a large extracellular region (p120) non-covalently linked to a seven-transmembrane moiety (p85). Interacts with syntaxin and with proteins of the SHANK family via the PDZ domain., |
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