Name: LDHA (Phospho Tyr10) rabbit pAb
SKU: WP10401
Price: 288 USD
Availability: InStock

LDHA (Phospho Tyr10) rabbit pAb

Ucallm_WP10401-50

Price range: $288.00 through $368.00

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100μl

50μl

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SKU: WP10401-100

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Product details

Background:

The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to exertional myoglobinuria. Multiple transcript variants encoding different isoforms have been found for this gene. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Sep 2008],

Specifications

Size	50μL/100μL
Target	LDHA Phospho Tyr10
Reactivity	Human
Applications	WB, ELISA, IHC
MW(Calculated)
MW(Observed)	36kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	phosphate
Recommended Dilution Ratio	WB 1:500-2000; IHC 1:50-300; ELISA 1:2000-20000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	Synthesized phosho peptide around human LDHA (Tyr10)
Specificity	This antibody detects endogenous levels of Human Mouse Rat LDHA (phospho-Tyr10)
Gene Name	LDHA PIG19
Protein Name	LDHA (Tyr10)
Other Name	L-lactate dehydrogenase A chain; / LDH-A; / Cell proliferation-inducing gene 19 protein; / LDH muscle subunit; / LDH-M; / Renal carcinoma antigen NY-REN-59
Species	Human
Gene ID	3939
Uniprot	P00338,
Species.1	Mouse
Gene ID.1	16828
Uniprot.1	P06151,
Species.2	Rat
Gene ID.2	24533
Uniprot.2	P04642
Cellular Localization	Cytoplasm.
Tissue Expression	Predominantly expressed in anaerobic tissues such as skeletal muscle and liver.
Signaling_pathway	Organismal Systems >> Endocrine system >> Glucagon signaling pathway;Human Diseases >> Cancer: overview >> Central carbon metabolism in cancer;Environmental Information Processing >> Signal transduction >> HIF-1 signaling pathway
Research Areas	>>Glycolysis / Gluconeogenesis; / >>Cysteine and methionine metabolism; / >>Pyruvate metabolism; / >>Propanoate metabolism; / >>Metabolic pathways; / >>HIF-1 signaling pathway; / >>Glucagon signaling pathway; / >>Central carbon metabolism in cancer
Function	Catalytic activity:(S)-lactate + NAD(+) = pyruvate + NADH.,Caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,Disease:Defects in LDHA are a cause of exertional myoglobinuria.,online information:Lactate dehydrogenase entry,pathway:Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.,similarity:Belongs to the LDH/MDH superfamily.,similarity:Belongs to the LDH/MDH superfamily. LDH family.,subunit:Homotetramer.,

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LDHA (Phospho Tyr10) rabbit pAb

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LDHA (Phospho Tyr10) rabbit pAb

Product details

Specifications

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