LDHA (Phospho Tyr10) rabbit pAb
Ucallm_WP10401-50
Price range: $288.00 through $368.00
Product details
Background:
The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to exertional myoglobinuria. Multiple transcript variants encoding different isoforms have been found for this gene. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Sep 2008],
Specifications
| Size | 50μL/100μL |
| Target | LDHA Phospho Tyr10 |
| Reactivity | Human |
| Applications | WB, ELISA, IHC |
| MW(Calculated) | |
| MW(Observed) | 36kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | phosphate |
| Recommended Dilution Ratio | WB 1:500-2000; IHC 1:50-300; ELISA 1:2000-20000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized phosho peptide around human LDHA (Tyr10) |
| Specificity | This antibody detects endogenous levels of Human Mouse Rat LDHA (phospho-Tyr10) |
| Gene Name | LDHA PIG19 |
| Protein Name | LDHA (Tyr10) |
| Other Name | L-lactate dehydrogenase A chain; / LDH-A; / Cell proliferation-inducing gene 19 protein; / LDH muscle subunit; / LDH-M; / Renal carcinoma antigen NY-REN-59 |
| Species | Human |
| Gene ID | 3939 |
| Uniprot | P00338, |
| Species.1 | Mouse |
| Gene ID.1 | 16828 |
| Uniprot.1 | P06151, |
| Species.2 | Rat |
| Gene ID.2 | 24533 |
| Uniprot.2 | P04642 |
| Cellular Localization | Cytoplasm. |
| Tissue Expression | Predominantly expressed in anaerobic tissues such as skeletal muscle and liver. |
| Signaling_pathway | Organismal Systems >> Endocrine system >> Glucagon signaling pathway;Human Diseases >> Cancer: overview >> Central carbon metabolism in cancer;Environmental Information Processing >> Signal transduction >> HIF-1 signaling pathway |
| Research Areas | >>Glycolysis / Gluconeogenesis; / >>Cysteine and methionine metabolism; / >>Pyruvate metabolism; / >>Propanoate metabolism; / >>Metabolic pathways; / >>HIF-1 signaling pathway; / >>Glucagon signaling pathway; / >>Central carbon metabolism in cancer |
| Function | Catalytic activity:(S)-lactate + NAD(+) = pyruvate + NADH.,Caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,Disease:Defects in LDHA are a cause of exertional myoglobinuria.,online information:Lactate dehydrogenase entry,pathway:Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.,similarity:Belongs to the LDH/MDH superfamily.,similarity:Belongs to the LDH/MDH superfamily. LDH family.,subunit:Homotetramer., |
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