Name: Leptin mouse mAb
SKU: WM0731
Price: 268 USD
Availability: InStock

Leptin mouse mAb

Ucallm_WM0731-50

Price range: $268.00 through $328.00

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50μl

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SKU: WM0731-50

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Product details

Background:
This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development. [provided by RefSeq, Jul 2008],

Specifications

Size	50μL/100μL
Target	Leptin
Reactivity	Human
Applications	ELISA
MW(Calculated)
MW(Observed)	16kD
Host Species	Mouse
Isotype
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	ELISA 1:10000-20000
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	6H8
Immunogen	Purified recombinant full length of human Leptin protein expressed in E.coli.
Specificity	This antibody detects human Leptin proteins.
Gene Name	LEP OB OBS
Protein Name	Leptin (Obese protein) (Obesity factor)
Other Name	FLJ94114; / LEP; / LEP_HUMAN; / LEPD; / Leptin; / murine obesity homolog; / Leptin; / obesity homolog, mouse; / Leptin; / Leptin Murine Obesity Homolog; / Leptin Precursor Obesity Factor; / OB; / Obese Protein; / Obese, mouse, homolog of; / Obesity; / Obesity factor; / Obesity factor; / Obesity homolog mouse; / Obesity Murine Homolog Leptin; / OBS; / OTTHUMP00000212285.
Species	Human
Gene ID	3952
Uniprot	P41159,
Species.1	Mouse
Gene ID.1	16846
Uniprot.1	P41160
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Secreted .
Tissue Expression	Adipose tissue is the main source of leptin. It is also produced by other peripheral tissues such as the skeletal muscle (PubMed:7789654, PubMed:16052473, PubMed:12448771). Expressed by intercalated and striated tracts of submandibular and parotid salivary gland intralobular ducts (PubMed:12448771). Detected by fundic epithelium of the gastric mucosa (PubMed:10896907). Secreted into blood and gastric juice (PubMed:10896907).
Signaling_pathway	Organismal Systems >> Endocrine system >> Adipocytokine signaling pathway;Environmental Information Processing >> Signal transduction >> JAK-STAT signaling pathway;Environmental Information Processing >> Signal transduction >> AMPK signaling pathway;Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction
Research Areas	>>Cytokine-cytokine receptor interaction; / >>Neuroactive ligand-receptor interaction; / >>AMPK signaling pathway; / >>JAK-STAT signaling pathway; / >>Adipocytokine signaling pathway; / >>Non-alcoholic fatty liver disease
Function	Disease:Defects in LEP may be a cause of autosomal recessive obesity [MIM:601665].,Function:May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass.,online information:Leptin entry,similarity:Belongs to the leptin family.,subunit:Interacts with SIGLEC6.,