SKU: WP16504 Categories: ,

LIPA2 rabbit pAb

Price range: $268.00 through $328.00

SKU: WP16504-100
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Product details

Background:

The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. It has been proposed that liprins are multivalent proteins that form complex structures and act as scaffolds for the recruitment and anchoring of LAR family of tyrosine phosphatases. This protein has been shown to bind the calcium/calmodulin-dependent serine protein kinase (MAGUK family) protein (also known as CASK) and proposed to regulate higher-order brain functions in mammals. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013],

Specifications

Size50μL/100μL
TargetLIPA2
ReactivityHuman, Mouse
ApplicationsWB, ELISA, IHC
MW(Calculated)138kD
MW(Observed)
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000; IHC 1:50-300; ELISA 1:2000-20000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from human LIPA2 AA range: 49-99
SpecificityThis antibody detects endogenous levels of LIPA2 at Human/Mouse
Gene NamePPFIA2
Protein NameLIPA2
Other Name
SpeciesHuman
Gene ID8499
UniprotO75334,
Species.1Mouse
Gene ID.1327814
Uniprot.1Q8BSS9
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationCytoplasm . Cell surface . Cell projection, dendritic spine . Colocalizes with PTPRF at the cell surface.
Tissue ExpressionExpressed only in brain.
Signaling_pathway
Research Areas
FunctionDomain:The N-terminal coiled coil regions mediate homodimerization preferentially and heterodimerization type alpha/alpha. The C-terminal, non-coiled coil regions mediate heterodimerization type alpha/beta and interaction with PTPRD, PTPRF and PTPRS.,Function:Alters PTPRF cellular localization and induces PTPRF clustering. May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates.,similarity:Belongs to the liprin family. Liprin-alpha subfamily.,similarity:Contains 3 SAM (sterile alpha motif) domains.,subcellular location:Colocalizes with PTPRF at the cell surface.,subunit:Forms homodimers and heterodimers with liprins-alpha and liprins-beta. Interacts with the second PTPase domain of PTPRD, PTPRF and PTPRS.,tissue specificity:Expressed only in brain.,
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