LONM rabbit pAb
Ucallm_WP3658-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a mitochondrial matrix protein that belongs to the Lon family of ATP-dependent proteases. This protein mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides in the mitochondrial matrix. It may also have a chaperone function in the assembly of inner membrane protein complexes, and participate in the regulation of mitochondrial gene expression and maintenance of the integrity of the mitochondrial genome. Decreased expression of this gene has been noted in a patient with hereditary spastic paraplegia (PMID:18378094). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2013],
Specifications
| Size | 50μL/100μL |
| Target | LONP1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | |
| MW(Observed) | 105kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human LONP1 AA range: 398-448 |
| Specificity | This antibody detects endogenous levels of LONP1 at Human/Mouse/Rat |
| Gene Name | LONP1 PRSS15 |
| Protein Name | LONM |
| Other Name | Lon protease homolog, mitochondrial; / LONHs; / Lon protease-like protein; / LONP; / Mitochondrial ATP-dependent protease Lon; / Serine protease 15 |
| Species | Human |
| Gene ID | 9361 |
| Uniprot | P36776, |
| Species.1 | Mouse |
| Gene ID.1 | 74142 |
| Uniprot.1 | Q8CGK3, |
| Species.2 | Rat |
| Gene ID.2 | 170916 |
| Uniprot.2 | Q924S5 |
| Cellular Localization | Mitochondrion matrix . |
| Tissue Expression | Duodenum, heart, lung and liver, but not thymus. |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Required for intramitochondrial proteolysis. Catalyzes the initial steps of protein degradation. Hydrolyzes ATP and degrades protein and peptide substrates in an ATP-dependent manner. Binds to single-stranded but not to double-stranded DNA.,similarity:Belongs to the peptidase S16 family.,similarity:Contains 1 Lon domain.,tissue specificity:Duodenum, heart, lung and liver, but not thymus., |
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