Price range: $268.00 through $328.00
Background:
This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. This integral membrane protein converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. A pseudogene of this gene is present on the Y chromosome. [provided by RefSeq, Aug 2014],
| Size | 50μL/100μL |
| Target | LPAAT-ε |
| Reactivity | Human, Mouse |
| Applications | WB, IHC |
| MW(Calculated) | |
| MW(Observed) | 45kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; IHC 1:50-300 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human AGPAT5. AA range:241-290 |
| Specificity | LPAAT-ε Polyclonal Antibody detects endogenous levels of LPAAT-ε protein. |
| Gene Name | AGPAT5 |
| Protein Name | 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon |
| Other Name | AGPAT5; / 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon; / 1-acylglycerol-3-phosphate O-acyltransferase 5; / 1-AGP acyltransferase 5; / 1-AGPAT 5; / Lysophosphatidic acid acyltransferase epsilon; / LPAAT-epsilon |
| Species | Human |
| Gene ID | 55326 |
| Uniprot | Q9NUQ2, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q9D1E8 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Endoplasmic reticulum membrane; Multi-pass membrane protein . Nucleus envelope . Mitochondrion . |
| Tissue Expression | Widely expressed. |
| Signaling_pathway | Environmental Information Processing >> Signal transduction >> Phospholipase D signaling pathway |
| Research Areas | >>Glycerolipid metabolism; / >>Glycerophospholipid metabolism; / >>Metabolic pathways; / >>Phospholipase D signaling pathway |
| Function | Catalytic activity:Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate.,Caution:It is uncertain whether Met-1 or Met-12 is the initiator.,Domain:The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.,Function:Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.,pathway:Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.,similarity:Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family., |
