Price range: $268.00 through $328.00
Background:
Mouse studies suggest that this gene functions during normal adipose tissue development and may play a role in human triglyceride metabolism. This gene represents a candidate gene for human lipodystrophy, characterized by loss of body fat, fatty liver, hypertriglyceridemia, and insulin resistance. [provided by RefSeq, Jul 2008],
| Size | 50μL/100μL |
| Target | LPIN2 |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 98kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 220-300 |
| Specificity | LPIN2 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | LPIN2 KIAA0249 |
| Protein Name | Phosphatidate phosphatase LPIN2 (Lipin-2) |
| Other Name | |
| Species | Human |
| Gene ID | 9663 |
| Uniprot | Q92539, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q99PI5 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus . Cytoplasm, cytosol . Endoplasmic reticulum membrane . Translocates to endoplasmic reticulum membrane with increasing levels of oleate. . |
| Tissue Expression | Expressed in liver, lung, kidney, placenta, spleen, thymus, lymph node, prostate, testes, small intestine, and colon. |
| Signaling_pathway | Environmental Information Processing >> Signal transduction >> mTOR signaling pathway |
| Research Areas | >>Glycerolipid metabolism; / >>Glycerophospholipid metabolism; / >>Metabolic pathways; / >>mTOR signaling pathway; / >>Alcoholic liver disease |
| Function | Disease:Defects in LPIN2 are the cause of Majeed syndrome [MIM:609628]. Majeed syndrome is an autosomal recessive disorder combining features of chronic recurrent multifocal osteomyelitis [MIM:259680], congenital dyserythropoietic anemia and inflammatory dermatosis.,online information:Repertory of FMF and hereditary autoinflammatory disorders mutations,similarity:Belongs to the lipin family.,tissue specificity:Expressed in liver, lung, kidney, placenta, spleen, thymus, lymph node, prostate, testes, small intestine, and colon., |
