Product details
Background:
LRRC8C rabbit pAb
Ucallm_WP8771-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | LRRC8C |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 88kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human LRRC8C |
| Specificity | This antibody detects endogenous levels of LRRC8C at Human, Mouse,Rat |
| Gene Name | LRRC8C AD158 FAD158 |
| Protein Name | Leucine-rich repeat-containing protein 8C (Factor for adipocyte differentiation 158) |
| Other Name | |
| Species | Human |
| Gene ID | 84230 |
| Uniprot | Q8TDW0, |
| Species.1 | Mouse |
| Gene ID.1 | 100604 |
| Uniprot.1 | Q8R502, |
| Species.2 | Rat |
| Gene ID.2 | 289443 |
| Uniprot.2 | Q498T9 |
| Cellular Localization | Cell membrane; Multi-pass membrane protein . Endoplasmic reticulum membrane . In the absence of LRRC8A, resides primarily in a cytoplasmic compartment, probably the endoplasmic reticulum. Requires LRRC8A for expression at the cell membrane. . |
| Tissue Expression | Expressed at highest levels in skeletal muscle, and at moderate levels in heart, lung and peripheral blood leukocytes. |
| Signaling_pathway | |
| Research Areas | |
| Function | Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes . The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine . Plays a redundant role in the efflux of amino acids, such as aspartate and glutamate, in response to osmotic stress . The VRAC channel also mediates transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol . Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition . |
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