Name: LUCA15 Polyclonal Antibody
SKU: WP13036
Price: 268 USD
Availability: InStock

LUCA15 Polyclonal Antibody

Ucallm_WP13036-50

Price range: $268.00 through $328.00

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50μl

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SKU: WP13036-100

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Product details

Background:

This gene is a candidate tumor suppressor gene which encodes a nuclear RNA binding protein that is a component of the spliceosome A complex. The encoded protein plays a role in the induction of cell cycle arrest and apoptosis through pre-mRNA splicing of multiple target genes including the tumor suppressor protein p53. This gene is located within the tumor suppressor region 3p21.3, and may play a role in the inhibition of tumor transformation and progression of several malignancies including lung cancer. [provided by RefSeq, Oct 2011],

Specifications

Size	50μL/100μL
Target	LUCA15
Reactivity	Human, Mouse
Applications	WB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)	92kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from human RBM5. AA range:226-275
Specificity	LUCA15 Polyclonal Antibody detects endogenous levels of LUCA15 protein.
Gene Name	RBM5
Protein Name	RNA-binding protein 5
Other Name	RBM5; / H37; / LUCA15; / RNA-binding protein 5; / Protein G15; / Putative tumor suppressor LUCA15; / RNA-binding motif protein 5; / Renal carcinoma antigen NY-REN-9
Species	Human
Gene ID	10181
Uniprot	P52756,
Species.1	Mouse
Gene ID.1	83486
Uniprot.1	Q91YE7
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Nucleus .
Tissue Expression	Isoform 5 is widely expressed in normal tissues and is expressed at increased levels in T-leukemic cell lines.
Signaling_pathway
Research Areas
Function	Function:Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate aopotosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis.,sequence Caution:Wrong choice of CDS.,similarity:Belongs to the RBM5/RBM10 family.,similarity:Contains 1 C2H2-type zinc finger.,similarity:Contains 1 G-patch domain.,similarity:Contains 1 RanBP2-type zinc finger.,similarity:Contains 2 RRM (RNA recognition motif) domains.,subunit:Component of the spliceosome A complex (also known as the prespliceosome). Appears to dissociate from the spliceosome upon formation of the spliceosome B complex (also known as the precatalytic spliceosome), in which the heterotrimeric U4/U6.U5 snRNPs are bound. Interacts with U2AF2; this interaction is direct. Also interacts with ACIN1, PRPF8, SFRS3, SNRPB, SNRPN, SNRNP70 and SNRNP200; these interactions may be indirect.,tissue specificity:Isoform 5 is widely expressed in normal tissues and is expressed at increased levels in T-leukaemic cell lines.,

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LUCA15 Polyclonal Antibody

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LUCA15 Polyclonal Antibody

Product details

Specifications

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