Lunatic Fringe Polyclonal Antibody
Ucallm_WP13037-50
Price range: $268.00 through $328.00
Product details
Background:
This gene is a member of the fringe gene family which also includes radical and manic fringe genes. They all encode evolutionarily conserved glycosyltransferases that act in the Notch signaling pathway to define boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, fringe proteins have a fucose-specific beta-1, 3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling. This gene product is predicted to be a single-pass type II Golgi membrane protein but it may also be secreted and proteolytically processed like the related proteins in mouse and Drosophila (PMID: 9187150). Mutations in this gene have been associated with autosomal recessive spondylocostal dysostosis 3. Multiple transcript variants encoding different isoforms
Specifications
| Size | 50μL/100μL |
| Target | Lunatic Fringe |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 42kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human LFNG. AA range:121-170 |
| Specificity | Lunatic Fringe Polyclonal Antibody detects endogenous levels of Lunatic Fringe protein. |
| Gene Name | LFNG |
| Protein Name | Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe |
| Other Name | LFNG; / Beta-1; / 3-N-acetylglucosaminyltransferase lunatic fringe; / O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase |
| Species | Human |
| Gene ID | 3955 |
| Uniprot | Q8NES3, |
| Species.1 | Mouse |
| Gene ID.1 | 16848 |
| Uniprot.1 | O09010, |
| Species.2 | Rat |
| Gene ID.2 | 170905 |
| Uniprot.2 | Q924T4 |
| Cellular Localization | Golgi apparatus membrane; Single-pass type II membrane protein . |
| Tissue Expression | Kidney, |
| Signaling_pathway | Environmental Information Processing >> Signal transduction >> Notch signaling pathway |
| Research Areas | >>Other types of O-glycan biosynthesis; / >>Notch signaling pathway; / >>Human papillomavirus infection |
| Function | Alternative products:Experimental confirmation may be lacking for some isoforms,Catalytic activity:Transfers a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor.,Caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,Disease:Defects in LFNG are the cause of spondylocostal dysostosis autosomal recessive type 3 (SCDO3) [MIM:609813]. Autosomal recessive spondylocostal dysostosis is a rare condition of variable severity associated with vertebral and rib segmentation defects. The main skeletal malformations include fusion of vertebrae, hemivertebrae, fusion of certain ribs, and other rib malformations. Deformity of the chest and spine (severe scoliosis, kyphoscoliosis and lordosis) is a natural consequence of the malformation and leads to a dwarf-like appearance. As the thorax is small, infants frequently have respiratory insufficiency and repeated respiratory infections resulting in life-threatening complications in the first year of life.,Function:Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Decreases the binding of JAGGED1 to NOTCH2 but not that of DELTA1. Essential mediator of somite segmentation and patterning.,online information:Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe,online information:GlycoGene database,PTM:A soluble form may be derived from the membrane form by proteolytic processing .,similarity:Belongs to the glycosyltransferase 31 family., |
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