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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/MADCA Polyclonal Antibody
SKU: WP1307 Categories: ,

MADCA Polyclonal Antibody

Ucallm_WP1307-50

Price range: $268.00 through $328.00

SKU: WP1307-100
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Product details

Background:

The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4beta7), L-selectin, and VLA-4 (alpha4beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin family and is similar to ICAM1 and VCAM1. At least seven alternatively spliced transcripts encoding different protein isoforms have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetMADCA
ReactivityHuman, Mouse, Rat
ApplicationsWB, ELISA
MW(Calculated)
MW(Observed)42kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000; ELISA 1:5000-20000
FormulationLiquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from human protein . at AA range: 260-340
SpecificityMADCA Polyclonal Antibody detects endogenous levels of protein.
Gene NameMADCAM1
Protein NameMucosal addressin cell adhesion molecule 1 (MAdCAM-1) (hMAdCAM-1)
Other Name
SpeciesHuman
Gene ID8174
UniprotQ13477,
Species.1Mouse
Gene ID.1
Uniprot.1Q61826,
Species.2Rat
Gene ID.2
Uniprot.2O70540
Cellular LocalizationMembrane; Single-pass type I membrane protein.
Tissue ExpressionHighly expressed on high endothelial venules (HEV) and lamina propia venules found in the small intestine, and to a lesser extent in the colon and spleen. Very low levels of expression found in pancreas and brain. Not expressed in the thymus, prostate, ovaries, testis, heart, placenta, lung, liver, skeletal muscle, kidney or peripheral blood leukocytes.
Signaling_pathwayOrganismal Systems >> Immune system >> Intestinal immune network for IgA production;Environmental Information Processing >> Signaling molecules and interaction >> Cell adhesion molecules
Research Areas>>Cell adhesion molecules; / >>Intestinal immune network for IgA production
FunctionAlternative products:Additional isoforms seem to exist,Function:Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding.,polymorphism:The number of repeats in the mucin domain varies between 5 and 8 repeats.,PTM:The Ser/Thr-rich mucin-like domain may provide possible sites for O-glycosylation.,similarity:Contains 2 Ig-like (immunoglobulin-like) domains.,subunit:Homodimer.,tissue specificity:Highly expressed on high endothelial venules (HEV) and lamina propia venules found in the small intestine, and to a lesser extent in the colon and spleen. Very low levels of expression found in pancreas and brain. Not expressed in the thymus, prostate, ovaries, testis, heart, placenta, lung, liver, skeletal muscle, kidneys or peripheral blood leukocytes.,
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