MafF Polyclonal Antibody
Ucallm_WP13054-50
Price range: $268.00 through $328.00
Product details
Background:
The protein encoded by this gene is a basic leucine zipper (bZIP) transcription factor that lacks a transactivation domain. It is known to bind the US-2 DNA element in the promoter of the oxytocin receptor (OTR) gene and most likely heterodimerizes with other leucine zipper-containing proteins to enhance expression of the OTR gene during term pregnancy. The encoded protein can also form homodimers, and since it lacks a transactivation domain, the homodimer may act as a repressor of transcription. This gene may also be involved in the cellular stress response. Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2009],
Specifications
| Size | 50μL/100μL |
| Target | MafF |
| Reactivity | Human, Mouse |
| Applications | IHC, IF, ELISA |
| MW(Calculated) | 18kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:100-1:300; ELISA 1:10000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human MAFF. AA range:51-100 |
| Specificity | MafF Polyclonal Antibody detects endogenous levels of MafF protein. |
| Gene Name | MAFF |
| Protein Name | Transcription factor MafF |
| Other Name | MAFF; / Transcription factor MafF; / U-Maf; / V-maf musculoaponeurotic fibrosarcoma oncogene homolog F |
| Species | Human |
| Gene ID | 23764 |
| Uniprot | Q9ULX9, |
| Species.1 | Mouse |
| Gene ID.1 | 17133 |
| Uniprot.1 | O54791 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus. |
| Tissue Expression | Expressed in the term myometrium and kidney. |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Interacts with the upstream promoter region of the oxytocin receptor gene. May be a transcriptional enhancer in the up-regulation of the oxytocin receptor gene at parturition. Since it lacks a putative transactivation domain, it may behave as a transcriptional repressor when it dimerize among himself. May also serve as a transcriptional activator by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. May be involved in the cellular stress response.,induction:By oxidative stress.,similarity:Belongs to the bZIP family.,similarity:Belongs to the bZIP family. Maf subfamily.,similarity:Contains 1 bZIP domain.,subunit:Monomer and homo- or heterodimer. Interacts with MIP.,tissue specificity:Expressed in the term myometrium and kidney., |
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