SKU: WM0756 Categories: ,

MAP2 [N-term] mouse mAb

Price range: $268.00 through $328.00

SKU: WM0756-50
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Product details

Background:
This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2010],

Specifications

Size50μL/100μL
TargetMAP-2
ReactivityHuman, Mouse
ApplicationsWB, IP, ICC
MW(Calculated)
MW(Observed)300kD
Host SpeciesMouse
Isotype
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:1000; ICC 1:150
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
ClonalityMonoclonal
Clone Number4D3
ImmunogenPurified recombinant human MAP2 (N-terminus) protein fragments expressed in E.coli
SpecificityThis antibody detects endogenous levels of MAP2 (N-terminus) and does not cross-react with related proteins.
Gene Namemap2
Protein Name
Other NameDKFZp686I2148; / Dendrite specific MAP; / DKFZp686I2148; / MAP 2; / MAP dendrite specific; / MAP-2; / MAP2; / MAP2A; / MAP2B; / MAP2C; / Microtubule associated protein 2; / Microtubule-associated protein 2; / Mtap 2; / MTAP2_HUMAN.
SpeciesHuman
Gene ID4133
UniprotP11137,
Species.1Mouse
Gene ID.1
Uniprot.1P20357
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationCytoplasm, cytoskeleton . Cell projection, dendrite .
Tissue ExpressionBrain,Brain cortex,Epithelium,Pancreas,Testis,
Signaling_pathway
Research Areas
FunctionAlternative products:Additional isoforms seem to exist,Function:The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.,PTM:MAP2A/c is phosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 3 Tau/MAP repeats.,similarity:Contains 4 Tau/MAP repeats.,
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