U-Blot® MAP2 Rabbit mAb
WR4578 Neuro-2a whole cell lysates were separated by 10% SDS-PAGE, and the membrane was blotted with primary antibody(1:1000). The HRP-conjugated Goat anti-Rabbit IgG(H + L) antibody was used to detect the antibody.
Price range: $268.00 through $328.00
Product details
Background:This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2010],
Specifications
| Size | 50μL/100μL |
| Target | MAP 2 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | 200kD |
| MW(Observed) | 280kD |
| Host Species | Rabbit |
| Isotype | IgG,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-1:1000; WB 1:1000-1:5000; IF 1:200-1:1000; ELISA 1:5000-1:20000; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RM0845R |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Endogenous |
| Gene Name | MAP2 |
| Protein Name | Microtubule-associated protein 2 |
| Other Name | MAP2; / Microtubule-associated protein 2; / MAP-2 |
| Species | Human |
| Gene ID | 4133 |
| Uniprot | P11137, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P20357, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | P15146 |
| Cellular Localization | Cytoplasm, cytoskeleton . Cell projection, dendrite . |
| Tissue Expression | Brain,Brain cortex,Epithelium,Pancreas,Testis, |
| Signaling_pathway | |
| Research Areas | |
| Function | Alternative products:Additional isoforms seem to exist,Function:The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.,PTM:MAP2A/c is phosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 3 Tau/MAP repeats.,similarity:Contains 4 Tau/MAP repeats., |
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