Product details
Background:
MCM-BP rabbit pAb
Ucallm_WP7592-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | MCMBP |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 71kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human MCM-BP |
| Specificity | This antibody detects endogenous levels of MCM-BP at Human, Mouse,Rat |
| Gene Name | MCMBP C10orf119 |
| Protein Name | Mini-chromosome maintenance complex-binding protein (MCM-BP) (MCM-binding protein) |
| Other Name | |
| Species | Human |
| Gene ID | 79892 |
| Uniprot | Q9BTE3, |
| Species.1 | Mouse |
| Gene ID.1 | 210711 |
| Uniprot.1 | Q8R3C0, |
| Species.2 | Rat |
| Gene ID.2 | 309009 |
| Uniprot.2 | B1H268 |
| Cellular Localization | Nucleus . Associates with chromatin. Highly associated with chromatin in G1/S and S phases, reduced binding to chromatin in G2, and further decreased binding in early M phase. It then reassociates with chromatin in late M phase. Dissociates from chromatin later than component of the MCM complex. |
| Tissue Expression | |
| Signaling_pathway | |
| Research Areas | |
| Function | Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion. |
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