ME2 Polyclonal Antibody
Ucallm_WP13118-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a mitochondrial NAD-dependent malic enzyme, a homotetrameric protein, that catalyzes the oxidative decarboxylation of malate to pyruvate. It had previously been weakly linked to a syndrome known as Friedreich ataxia that has since been shown to be the result of mutation in a completely different gene. Certain single-nucleotide polymorphism haplotypes of this gene have been shown to increase the risk for idiopathic generalized epilepsy. Alternatively spliced transcript variants encoding different isoforms found for this gene. [provided by RefSeq, Dec 2009],
Specifications
| Size | 50μL/100μL |
| Target | ME2 |
| Reactivity | Human, Mouse |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 65kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human ME2. AA range:201-250 |
| Specificity | ME2 Polyclonal Antibody detects endogenous levels of ME2 protein. |
| Gene Name | ME2 |
| Protein Name | NAD-dependent malic enzyme mitochondrial |
| Other Name | ME2; / NAD-dependent malic enzyme; / mitochondrial; / NAD-ME; / Malic enzyme 2 |
| Species | Human |
| Gene ID | 4200 |
| Uniprot | P23368, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q99KE1 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Mitochondrion matrix . |
| Tissue Expression | B-cell,Placenta,Platelet, |
| Signaling_pathway | |
| Research Areas | >>Pyruvate metabolism; / >>Carbon metabolism |
| Function | Catalytic activity:(S)-malate + NAD(+) = pyruvate + CO(2) + NADH.,cofactor:Divalent metal cations. Prefers magnesium or manganese.,enzyme regulation:Subject to allosteric activation by fumarate.,miscellaneous:This isoenzyme can also use NADP(+) but is more effective with NAD(+).,similarity:Belongs to the malic enzymes family.,subunit:Homotetramer., |
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