Name: MEK-7 Polyclonal Antibody
SKU: WP13138
Price: 268 USD
Availability: InStock

Product details

Background:

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2, MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014],

Specifications

Size	50μL/100μL
Target	MKK7
Reactivity	Human, Mouse, Rat
Applications	WB, IHC
MW(Calculated)
MW(Observed)	47kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-2000; IHC 1:50-300 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from human MAP2K7. AA range:241-290
Specificity	MEK-7 Polyclonal Antibody detects endogenous levels of MEK-7 protein.
Gene Name	MAP2K7
Protein Name	Dual specificity mitogen-activated protein kinase kinase 7
Other Name	MAP2K7; / JNKK2; / MEK7; / MKK7; / PRKMK7; / SKK4; / Dual specificity mitogen-activated protein kinase kinase 7; / MAP kinase kinase 7; / MAPKK 7; / JNK-activating kinase 2; / MAPK/ERK kinase 7; / MEK 7; / Stress-activated protein kinase kinase 4; / SAPK kinase 4; / S
Species	Human
Gene ID	5609
Uniprot	O14733,
Species.1	Mouse
Gene ID.1	26400
Uniprot.1	Q8CE90,
Species.2	Rat
Gene ID.2	363855
Uniprot.2	Q4KSH7
Cellular Localization	Nucleus. Cytoplasm .
Tissue Expression	Ubiquitous; with highest level of expression in skeletal muscle. Isoform 3 is found at low levels in placenta, fetal liver, and skeletal muscle.
Signaling_pathway	Cellular Processes >> Cellular community - eukaryotes >> Tight junction;Organismal Systems >> Immune system >> Toll-like receptor signaling pathway;Organismal Systems >> Immune system >> T cell receptor signaling pathway;Organismal Systems >> Immune system >> Fc epsilon RI signaling pathway;Organismal Systems >> Endocrine system >> GnRH signaling pathway;Organismal Systems >> Endocrine system >> Relaxin signaling pathway;Organismal Systems >> Nervous system >> Neurotrophin signaling pathway;Organismal Systems >> Development and regeneration >> Osteoclast differentiation;Human Diseases >> Neurodegenerative disease >> Alzheimer disease;Human Diseases >> Neurodegenerative disease >> Huntington disease;Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases;Environmental Information Processing >> Signal transduction >> MAPK signaling pathway;Environmental Information Processing >> Signal transduction >> ErbB signaling pathway;Environmental Information Processing >> Signal transduction >> TNF signaling pathway
Research Areas	>>MAPK signaling pathway; / >>ErbB signaling pathway; / >>Protein processing in endoplasmic reticulum; / >>Osteoclast differentiation; / >>Tight junction; / >>Toll-like receptor signaling pathway; / >>T cell receptor signaling pathway; / >>Fc epsilon RI signaling pathway; / >>TNF signaling pathway; / >>Neurotrophin signaling pathway; / >>GnRH signaling pathway; / >>Relaxin signaling pathway; / >>Alcoholic liver disease; / >>Alzheimer disease; / >>Huntington disease; / >>Pathways of neurodegeneration - multiple diseases; / >>Salmonella infection; / >>Yersinia infection; / >>Hepatitis B; / >>Kaposi sarcoma-associated herpesvirus infection; / >>Epstein-Barr virus infection; / >>Human immunodeficiency virus 1 infection; / >>Chemical carcinogenesis - reactive oxygen species; / >>Lipid and atherosclerosis; / >>Fluid shear stress and atherosclerosis
Function	Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by phosphorylation by specific MAP kinase kinase kinases such as MAP3K1/MEKK1, MAP3K3/MEKK3, MAP3K11/MLK3 and MAP3K12/DLK.,Function:Stress activated, dual specificity kinase that activates the JUN kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3.,PTM:Activated by phosphorylation on Ser/Thr.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.,similarity:Contains 1 protein kinase domain.,tissue specificity:Ubiquitous; with highest level of expression in skeletal muscle. Isoform 3 is found at low levels in placenta, fetal liver, and skeletal muscle.,

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MEK-7 Polyclonal Antibody

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MEK-7 Polyclonal Antibody

Product details

Specifications

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