SKU: WP13140 Categories: ,

MEL-1B-R Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP13140-100
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Product details

Background:

This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This gene product is an integral membrane protein that is a G-protein coupled, 7-transmembrane receptor. It is found primarily in the retina and brain although this detection requires RT-PCR. It is thought to participate in light-dependent functions in the retina and may be involved in the neurobiological effects of melatonin. [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetMEL-1B-R
ReactivityHuman
ApplicationsWB, IHC
MW(Calculated)
MW(Observed)40kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000; IHC 1:50-300 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from human MTR1B. AA range:301-350
SpecificityMEL-1B-R Polyclonal Antibody detects endogenous levels of MEL-1B-R protein.
Gene NameMTNR1B
Protein NameMelatonin receptor type 1B
Other NameMTNR1B; / Melatonin receptor type 1B; / Mel-1B-R; / Mel1b receptor
SpeciesHuman
Gene ID4544
UniprotP49286,
Species.1Mouse
Gene ID.1
Uniprot.1Q8CIQ6
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationCell membrane; Multi-pass membrane protein.
Tissue ExpressionExpressed in retina and less in brain and hippocampus.
Signaling_pathway
Research Areas>>Neuroactive ligand-receptor interaction; / >>Circadian entrainment
FunctionFunction:High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.,online information:Melatonin receptor entry,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Expressed in retina and less in brain and hippocampus.,
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